[1]黄艳,黄成,李俊.肝纤维化病程中Kupffer细胞分泌的细胞因子对肝星状细胞活化增殖、凋亡的调控[J].中国药理学通报,2010,(01):9-13.
 HUANG Yan,HUANG Cheng,LI Jun.Effect of cytokines secreted from Kupffer cell on HSC proliferation, apoptosis in hepatic fibrosis process[J].Chinese Pharmacological Bulletin,2010,(01):9-13.
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肝纤维化病程中Kupffer细胞分泌的细胞因子对肝星状细胞活化增殖、凋亡的调控()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2010年01期
页码:
9-13
栏目:
讲座与综述
出版日期:
2010-01-25

文章信息/Info

Title:
Effect of cytokines secreted from Kupffer cell on HSC proliferation, apoptosis in hepatic fibrosis process
作者:
黄艳黄成李俊
安徽医科大学药学院,安徽天然药物活性研究省级实验室,国家中医药管理局中医药科研三级实验室“中药药理实验室”,安徽 合肥230032
Author(s):
HUANG YanHUANG ChengLI Jun
Dept of Pharmacology,Anhui Medical University,Hefei230032,China
关键词:
肝星状细胞枯否细胞细胞因子肝纤维化增殖凋亡
Keywords:
HSCKupffer cellcytokinehepatic fibrosisproli ferationapoptosis
分类号:
R 322.47;R 329.24;R 329.25;R 392.12
文献标志码:
A
摘要:
肝纤维化是对慢性肝损伤的愈合反应,为一个可逆的过程。肝星状细胞(hepatic stellate cell,HSC)是肝脏分泌细胞外基质(extra cellular matrixc,ECM)的主要细胞,在肝纤维化的发展机制中占有重要的地位。如何控制HSC的活性并逆转肝纤维化的进程是抗肝纤维化研究的重点之一。在肝纤维化病程中,一系列细胞因子通过旁分泌和自分泌方式作用于邻近的HSC,影响其增殖、趋化、代谢及凋亡。鉴于Kupffers细胞为细胞因子的主要来源,其在肝纤维化病程中对HSC细胞的活化增殖、凋亡发挥着重要的调控作用。HSC、Kupffers细胞及细胞因子与肝纤维化的发生发展关系极为密切,阐明其关系,有助于以HSC为靶点的肝纤维化方面的研究,现就其关系综述如下。
Abstract:
Liver fibrosis can be caused by chronic liver injury arising from various etiological factors and it is a reversible process.The activation of the hepatic stellate cell(HSC)is the central event in liver fibrosis,since we know that cytokines secreted from Kupffer cell participate in HSC proliferation,apoptosis and ECM metabolism.In this paper we focus on the relationship between HSCs,Kupffer cell,cytokines and the course of hepatic fibrosis.Elucidating this relationship will benefit research on the role of Kupffer and HSCs in hepatic fibrosis.

参考文献/References:

[1]Shek F W,Benyon R C.How can transforming growth factor beta be targeted usefully to combat liver fibrosis[J]?Eur J Gastroenterol Hepatol,2004,16:123-6.
[2]陈小亮,李俊,邓子煜,等.苦参素对肝纤维化大鼠肝脏TGFβ1的调节作用[J].中国药理学通报,2009,25(6):761-4.
[2]Chen X L,Li J,Deng Z Y,et al.Regulating effect of oxymatrine on TGFβ1 in CCl4induced hepatic fibrosis rats[J].Chin Pharmacol Bull,2009,25(6):761-4.
[3]Cheng K,Yang N,Mahato R I.TGFbeta1 gene silencing for treating liver fibrosis[J].Mol Pharm,2009,6(3):772-9.
[4]Si H F,Li J,Lü X,et al. Suppressive effect of leflunomide on rat hepatic stellate cell proliferation involves on PDGFBBelicited activation of three mitogenactivated protein kinases[J].Cytokine,2008,42:24-31.
[5]Tomita K,Tamiya G,Ando S,et al.Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essentiaI role in liver fibrosis of nonaltoholic steatohepatitis in mice[J].Gut,2006,55:415-24.
[6]Migita K,Maeda Y,Abiru S,et al.Immunosuppressant FK506 inhibits matrix metalloproteinase9 induction in TNFalphastimulated human hepatic stellate cells[J].Life Sci,2006,78(21):2510-5.
[7]Novo E,Marra F,Zamara E,et al.Overexpression of Bcl2 by activated human hepatic stellate cells:resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans[J].Gut,2006,55(8):1174-82.
[8]万荣,吴云林,乔敏敏,等. 胰岛素样生长因子1对大鼠肝纤维化形成的影响[J]. 世界华人消化杂志,2005,13(2):211-3.
[8]Wan R, Wu Y L,Qiao M M,et al.Effect of insulinlike growth factor1 on hepatic fibrosis in rats [J].World Chin J Digestol,2005,13(2):211-3.
[9]刘立新,张骞骞,韩德五,等.IGFBP2、IGFBP6在TGFβ1活化的肝星状细胞中表达[J].中国病理生理杂志,2008,24(12):2481-3.
[9]Liu L X,Zhang Q Q,Han D W,et al.Expression of IGFBP2 and IGFBP6 in TGFβ1 activated HSC[J].Chin J Pathophysiol,2008,24(12):2481-3.
[10]Vera M,Sobrevals L,Zaratiegui M,et al.Liver transduction with a simian virus 40 vector encoding insulinlike growth factor I reduces hepatic damage and the development of liver cirrhosis[J].Gene Ther,2007,14(3):203-10.
[11]徐燕,杜文军,秦来英,等.白细胞介素17在乙肝肝纤维化中的表达及意义[J].细胞与分子免疫学杂志,2009,25(2):133-5.
[11] Xu Y,Du W J,Qin L Y,et al.Expression of interleukin17 in hepatitis B related liver fibrosis[J].Chin J Cell Mol Immunol,2009,25(2):133-5.
[12]Zheng W D,Zhang L J,Shi M N,et al.Expression of matrix metalloproteinase2 and tissue inhibitor of metalloproteinase1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL10[J].World J Gastroenterol,2005,11(12):1753-8.
[13]Tang X,Yang J,Li J.Sensitization of human hepatic stellate cells to tumor necrosis factorrelated apoptosisinducing ligandinduced apoptosis by leflunomide[J].Biol Pharm Bul,2009,32(6):963-7.
[14]Son G,Iimuro Y,Seki E,et al.Selective inactivation of NFkappaB in the liver using NFkappaB decoy suppresses CCl4induced liver injury and fibrosis [J].Am J Physiol Gastrointest Liver Physiol,2007,293(3):G631-9.
[15]Bethanis S K,Theocharis S E.Leptin in the field of hepatic fibrosis:a pivotal or an incidental player[J]?Dig Dis Sci,2006,51(10):1685-96.
[16]Honda H,Ikejima K,Yoshikawa M,et al.Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver[J].Hepatology,2002,36(1):12-21.
[17]农兵,罗和生,梁增文,等.瘦素在实验性大鼠肝纤维化发生中的作用机制研究[J].华夏医学,2006,19(3):386-8.
[18]Nong B,Luo H S,Liang Z W,et al.Relationship between leptin and liver fibrogenesis of rats[J].Acta Med Sin,2006,19(3):386-8.
[19]Wang J,Leclercq I,Brymora J M,et al.kupffer cells mediate leptininduced liver fibrosis[J].Gastroenterology,2009,137(2):713-23.
[20]Si H F,Li J,Lü X,et al.Suppressive effects of leflunomide on leptininduced collagen I production involved in hepatic stellate cell proliferation[J].Exp Biol Med,2007,232(3):427-36.
[21]Li J, Si HF, Lü X, et al. Suppressive effects of leflunomide on leptininduced TIMP1 production involves on hepatic stellate cell proliferation and apoptosis[J].Eur J Pharmacol,2008,580(12):63-9.
[22]Kumada M,Kihara S,Ouchi N,et al.Adiponectin specifically increased tissue inhibitor of metalloproteinase1 through interleukin10 expression in human macrophages[J].Circulation,2004,109(17):2046-9.
[23]Liu J,Gong H,Zhang Z T,et al.Effect of angiotensin Ⅱ and angiotensin Ⅱ type 1 receptor antagonist on the proliferation,contraction and collagen synthesis in rat hepatic stellate cells[J].Chin Med J(Engl),2008,121(2):161-5.
[24]Bezugla Y,Kolada A,Kamionka S,et al.COXl and COX2 contribute differentially to the LPSinduced release of PGE2 and TxA2 in liver macrophages[J].Prostaglandins Other Lipid Mediat,2006,79(1-2):93-100.
[25]Gaca M D,Zhou X,Issa R,et al.Basement membranelike matrix inhibits proliferation and collagen synthesis by activatedrat hepatic stellate cells:evidence for matrixdependent deactivation of stellate cells[J].Matrix Biol,2003,22:229-39.
[26]Duffield J S,Forbes S J,Constandinou C M,et al.Selective depletion of macrophages reveals distinct,opposing roles during liver injury and repair[J].J Clin Invest,2005,115(1):56-65.
[27]Fischer R,Cariers A,Reinehr R,et al.Caspase 9dependent killing of hepatic stellate cells by activated Kupffer cells[J].Gastroenterology,2002,123(3):845-61.
[28]Friedman S L. Mac the knife? Macrophages—the doubleedged sword of hepatic fibrosis[J]. J Clin Invest, 2005,115(1):29-32.
[29]平键,成扬,徐列明.姜黄素通过激活过氧化物酶体增殖子活化受体γ诱导肝星状细胞凋亡[J].中国药理学通报,2007,23(10):1295-9.
[29]Ping J,Cheng Y,Xu L M.Curcumin induces apoptosis of hepatic stellate cells by activating peroxisome proliferatoractivated receptor γ signal[J].Chin Pharmacol Bull,2007,23(10):1295-9.
[30]张怡,平洁,汪晖.肝星状细胞凋亡信号途径及其药物治疗的研究进展[J].中国药理学通报,2009,25(1):16-8.
[30]Zhang Y,Ping J,Wang H.The research progress of hepatic stellate cell′s apoptosis signaling pathway and the relative drugs[J].Chin Pharmacol Bull,2009,25(1):16-8.
[31]孙利兵,王尉平,顾振纶,等.Wnt信号转导通路与肝纤维化[J].中国药理学通报,2008,24(7):861-4.
[31]Sun L B,Wang W P,Gu Z L,et al.Wnt signalling pathway and hepatic fibrosis[J].Chin Pharmacol Bull,2008,24(7):861-4.
[32]Tang X,Yang J, Li J. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAILmediated hepatic stellate cell apoptosis[J].Life Sci,2009,84(15-16): 552-7.
[33]Mahalingam D,Szegezdi E,Keane M,et al.TRAIL receptor signalling and modulation:Are we on the right TRAIL[J]?Cancer Treat Rev,2009,35(3):280-8.

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备注/Memo

备注/Memo:
收稿日期:2009-08-02,修回日期:2009-10-20基金项目:国家自然科学基金资助项目(No 30873081,30672475);安徽省自然科学基金资助项目(No 090413134);高等学校优秀青年人才基金重点资助项目(No 2009SQRZ049ZD);安徽医科大学校博士启动基金资助项目(No XJ200803)作者简介:黄艳(1979-),女,博士,副教授,研究方向:抗炎免疫药理学、中药药理学,Tel:05515161217,Email:aydhy@126.com;李俊(1960-),男,博士,教授,博士生导师,研究方向:抗炎免疫及临床药理学,通讯作者,Tel:05515161001,Email:lijun@ahmu.edu.cn
更新日期/Last Update: 2010-01-25