[1]郭秋平,杨 威,郭 琳,等.对乙酰氨基酚SD大鼠毒代动力学研究及P450的影响[J].中国药理学通报,2014,(08):1183.
 GUO Qiu-ping,YANG Wei,GUO Lin,et al.Study on rats P450 and toxicokinetics induced by APAP[J].Chinese Pharmacological Bulletin,2014,(08):1183.
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对乙酰氨基酚SD大鼠毒代动力学研究及P450的影响()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2014年08期
页码:
1183
栏目:
研究简报
出版日期:
2014-08-15

文章信息/Info

Title:
Study on rats P450 and toxicokinetics induced by APAP
作者:
郭秋平12杨 威3郭 琳3覃仁安1金若敏2
1.广州白云山和记黄埔中药有限公司博士后工作站,广东 广州 510515;
2.上海中医药大学培养博士后流动站, 上海 201203;
3. 广州医药研究总院有限公司药物非临床评价研究中心,广东 广州 510240
Author(s):
GUO Qiu-ping YANG Wei GUO Lin QIN Ren-an JIN Ruo-min
1. Postdoctoral Workstation of Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co.LTD,Guangzhou 510515, China;
2. Postdoctoral Workstation of Shanghai Traditional Chinese Medicine University, Shanghai 201203,China;
3. Guangzhou General Pharmaceutical Research Institute Drug Non Clinical Evaluation and Research Center, Guangzhou 510240, China
关键词:
对乙酰氨基酚 毒代动力学 P450 药物蓄积
Keywords:
APAP toxicokinetics P450 drug accumulation
文献标志码:
A

参考文献/References:

[1] Amar P J, Schiff E R. Acetaminophen safety and hepatotoxicity-where do we go from here[J]? Expert Opin Drug Saf, 2007, 6(4):341-55.
[2] Shayiq R M, Roberts D W, Rothestein K, et al. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen induced lethality in mice[J]. Hepatology, 1999, 29(2):451-63.
[3] Fannin R D, Russo M, O'Connell T M, et al. Acetaminophen dosing of humans results in blood transcriptom and metabolome changes consistent with impaired oxidative phosphorylation[J]. Hepatology, 2010, 51(1):227-36.
[4] Koop D R. Oxidative and reductive metabolism by cytochrome P450 2E1[J].FASEB J, 1992, 6(2):724-30.
[5] Koster U, Speerschneider P, Kerssebaum R, et al. Role of cyctochrome P4502E1 in themetabolism of 1, 1, 2, 2, 32 hexafluoropropylmethylether[J]. Drug Metab Dispos, 1994, 22(5): 667-72.

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备注/Memo

备注/Memo:
收稿日期:2014-04-02,修回日期:2014-05-08
基金项目:广州博士后科研项目; 珠江科技新星项目(No 2011070)
作者简介:郭秋平(1978-),女,博士,博士后,高级工程师,研究方向:药理毒理学,Tel:020-66284080,E-mail:vipvivenguoguo@126.com; 杨 威(1978-),男,博士,高级工程师,研究方向:药理毒理学,Tel:020-66284078,E-mail:yangwei0719@163.com,共同第一作者; 金若敏(1948-),女,教授,博士生导师,研究方向:药理与毒理学,通讯作者,Tel:021-51322401,E-mail:rmj801@126.com
更新日期/Last Update: 1900-01-01