PENG Li chao,LIANG Shang dong.Recent research progress on the role of gap junction in neuropathic pain[J].Chinese Pharmacological Bulletin,2015,(02):157-161.





Recent research progress on the role of gap junction in neuropathic pain
南昌大学基础医学院生理学教研室,江西 南昌330006
PENG LichaoLIANG Shangdong
Dept of Physiology, Basic Medical College of Nanchang University, Nanchang330006, China
gap junction connexin nervous system glial cells neuropathic pain gap junction blocker
Gap junctions are specialized transmembrane channels that enable the direct exchange of materials and transfer chemical or electrical signaling between adjacent cells, thus maintaining cellular homeostasis. In the nervous system, gap junction channels not only mediate intercellular coupling between neurons and between glial cells, but also can be involved in secondary damage under pathological conditions. Recently, some studies have shown that gap junctions play an important role in neuropathic pain caused by nervous system damage. Research on the role of gap junctions in neuropathic pain can contribute to a deeper understanding of the pathogenesis of neuropathic pain, providing a new research direction for the treatment of neuropathic pain.


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收稿日期:2014-10-27,修回日期:2014-11-25 基金项目:国家自然科学基金资助项目(No 81171184, 31060139, 30860086);第二批江西省“赣鄱英才555工程”领军人才项目;江西省自然科学基金资助项目(No 20142BAB205028);江西省教育厅科技项目(No GJJ13155) 作者简介:彭力超(1990-),女,硕士生,研究方向:神经生理学与病理生理学, Email: 836615177@qq.com; 梁尚栋(1957-),男,博士,教授,博士生导师,研究方向:神经生理学与神经药理学, 通迅作者,Email: liangsd88@163.com
更新日期/Last Update: 1900-01-01