[1]彭力超,梁尚栋.缝隙连接与神经病理性痛的研究进展[J].中国药理学通报,2015,(02):157-161.
 PENG Li chao,LIANG Shang dong.Recent research progress on the role of gap junction in neuropathic pain[J].Chinese Pharmacological Bulletin,2015,(02):157-161.
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缝隙连接与神经病理性痛的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2015年02期
页码:
157-161
栏目:
讲座与综述
出版日期:
2015-02-15

文章信息/Info

Title:
Recent research progress on the role of gap junction in neuropathic pain
作者:
彭力超梁尚栋
南昌大学基础医学院生理学教研室,江西 南昌330006
Author(s):
PENG LichaoLIANG Shangdong
Dept of Physiology, Basic Medical College of Nanchang University, Nanchang330006, China
关键词:
缝隙连接连接蛋白神经系统胶质细胞神经病理性痛缝隙连接阻断剂
Keywords:
gap junction connexin nervous system glial cells neuropathic pain gap junction blocker
分类号:
R05;R322.8;R329.24;R441.1;R741.02
文献标志码:
A
摘要:
缝隙连接是介导相邻细胞间物质转运、化学或电信号传递的专用跨膜通道,维持着细胞内环境的稳定。在神经系统中,缝隙连接不仅介导神经元和胶质细胞的胞间偶合,还参与病理条件下继发性损害。目前,研究证明缝隙连接在由神经系统损伤引起的神经病理性痛中发挥作用。对缝隙连接与神经病理性痛的关系进行研究有助于更深层次的了解神经病理性痛的发病机制,为治疗神经病理性痛提供新的研究方向。
Abstract:
Gap junctions are specialized transmembrane channels that enable the direct exchange of materials and transfer chemical or electrical signaling between adjacent cells, thus maintaining cellular homeostasis. In the nervous system, gap junction channels not only mediate intercellular coupling between neurons and between glial cells, but also can be involved in secondary damage under pathological conditions. Recently, some studies have shown that gap junctions play an important role in neuropathic pain caused by nervous system damage. Research on the role of gap junctions in neuropathic pain can contribute to a deeper understanding of the pathogenesis of neuropathic pain, providing a new research direction for the treatment of neuropathic pain.

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备注/Memo

备注/Memo:
收稿日期:2014-10-27,修回日期:2014-11-25 基金项目:国家自然科学基金资助项目(No 81171184, 31060139, 30860086);第二批江西省“赣鄱英才555工程”领军人才项目;江西省自然科学基金资助项目(No 20142BAB205028);江西省教育厅科技项目(No GJJ13155) 作者简介:彭力超(1990-),女,硕士生,研究方向:神经生理学与病理生理学, Email: 836615177@qq.com; 梁尚栋(1957-),男,博士,教授,博士生导师,研究方向:神经生理学与神经药理学, 通迅作者,Email: liangsd88@163.com
更新日期/Last Update: 1900-01-01