[1]曹玉珠,刘兆国,单云龙,等.血小板介导肿瘤血行转移的作用及其机制研究进展[J].中国药理学通报,2015,(02):166-169.
 CAO Yu zhu,LIU Zhao guo,SHAN Yun long,et al.Research progress on the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms[J].Chinese Pharmacological Bulletin,2015,(02):166-169.
点击复制

血小板介导肿瘤血行转移的作用及其机制研究进展()
分享到:

《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2015年02期
页码:
166-169
栏目:
讲座与综述
出版日期:
2015-02-15

文章信息/Info

Title:
Research progress on the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms
作者:
曹玉珠1刘兆国1单云龙1孙丽华1刘玉萍1韦忠红1祝娉婷1吴红雁1王爱云1陈文星1郑仕中12陆茵12
1.南京中医药大学药学院,江苏 南京210023;2.江苏省中药药效与安全性评价重点实验室,江苏 南京210023
Author(s):
CAO Yuzhu1 LIU Zhaoguo1 SHAN Yunlong1 SUN Lihua1 LIU Yuping1 WEI Zhonghong1 ZHU Pinting1 WU Hongyan1 WANG Aiyun1 CHEN Wenxing1ZHENG Shizhong12 LU Yin12
1.College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing210023, China; 2.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medicine,Nanjing210023, China
关键词:
血小板瘤栓肿瘤血行转移分子机制治疗策略临床应用
Keywords:
platelet tumor embolus tumor hematogenous spread molecular mechanisms therapy strategies clinical application
分类号:
R05;R331.124;R3313;R7337;R7302
文献标志码:
A
摘要:
肿瘤转移是恶性肿瘤最为重要的生物学特性之一,同时也是影响预后及导致治疗失败的主要因素。临床研究显示,恶性肿瘤患者的血小板数目较正常人及良性肿瘤患者明显升高,表明血小板可能参与了肿瘤的发生发展过程。进一步研究发现,血小板在肿瘤血行转移的过程中能够与肿瘤细胞相互作用形成瘤栓,逃避免疫监视,进而促进了肿瘤的转移。近年来,临床上已经开展了针对血小板治疗肿瘤转移的研究,同时,血小板促进肿瘤转移的相关作用机制也逐步地被揭示。该文对近年来血小板介导肿瘤血行转移的作用及其作用机制研究进展进行综述,探讨临床针对血小板治疗肿瘤转移的策略,为后续的科学研究及指导临床提供参考。
Abstract:
Tumor metastasis is one of the most important biological characteristics of malignant tumor, and it is also the main factors that cause treatment failure and poor prognosis. Clinical studies have shown that the number of platelets in patients with malignant tumor increased more significantly than that in benign tumor patients and healthy people, which indicate that platelet might be involved in the development process of tumor. Further study found that in the process of cancer spreading to blood, platelet could interact with tumor cells to form tumor emboli, helped tumor cells escape from immune surveillance, thus promoted the tumor metastasis. In recent years, related mechanisms on platelets in promoting tumor metastasis were revealed gradually, and several targeted therapies based on platelets were also carried out. This paper reviews the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms and discusses the therapy strategies that target platelet, which may provide references for followup research and clinical treatment.

参考文献/References:

[1]Erpenbeck L, Schn M P. Deadly allies: the fatal interplay between platelets and metastasizing cancer cells[J]. Blood, 2010, 115(17):3427-36.
[2]Schumacher D, Strilic B, Sivaraj K K, et al. Plateletderived nucleotides promote tumorcell transendothelial migration and metastasis via P2Y2 receptor[J]. Cancer Cell, 2013, 24(1):130-7.
[3]Simanek R, Vormittag R, Ay C, et al. High platelet count associated with venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS)[J]. J Thromb Haemost, 2010, 8(1):114-20.
[4]Labelle M, Begum S, Hynes R O. Direct signaling between platelets and cancer cells induces an epithelialmesenchymallike transition and promotes metastasis[J]. Cancer Cell, 2011, 20(5):576-90.
[5]Ware J, Corken A, Khetpal R. Platelet function beyond hemostasis and thrombosis [J]. Curr Opin Hematol, 2013, 20(5):451-6.
[6]Heemskerk J W, Mattheij N J, Cosemans J M. Plateletbased coagulation: different populations, different functions[J]. J Thromb Haemost, 2013, 11(1):2-16.
[7]Roh J W, Huang J, Hu W, et al. Biologic effects of plateletderived growth factor receptor α blockade in uterine cancer[J]. Clin Cancer Res, 2014, 20(10):2740-50.
[8]Huang H S, Chang H H. Platelets in inflammation and immune modulations: functions beyond hemostasis[J]. Arch Immunol Ther Exp (Warsz), 2012, 60(6):443-51.
[9]Ozaki Y, SuzukiInoue K, Inoue O. Platelet receptors activated viamulitmerization: glycoprotein VI, GPIbIXV, and CLEC2[J]. J Thromb Haemost, 2013, 11 Suppl 1:330-9.
[10]Takagi S, Sato S, Ohhara T, et al. Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC2. [J]. PLoS One, 2013, 8(8): e73609.
[11]Mitrugno A, Williams D, Kerrigan S W, et al. A novel and essential role for FcγRIIa in cancer cellinduced platelet activation[J]. Blood, 2014, 123 (2): 249-60.
[12]Wang H, Gao J, Bai M, et al. The pretreatment platelet and plasma fibrinogen level correlate with tumor progression and metastasis in patients with pancreatic cancer[J]. Platelets, 2014, 25(5):382-7.
[13]Wang Y, Sun Y, Li D, et al. Platelet P2Y12 is involved in murine pulmonary metastasis[J]. PLoS One, 2013, 8(11):e80780.
[14]Tsuruo T, Fujita N. Platelet aggregation in the formation of tumor metastasis[J]. Proc Jpn Acad Ser B Phys Biol Sci, 2008, 84(6):189-98.
[15]Zhang N, Zhang W J, Cai H Q, et al. Platelet adhesion and fusion to endothelial cell facilitate the metastasis of tumor cell in hypoxiareoxygenation condition[J]. Clin Exp Metastasis, 2011, 28(1):1-12.
[16]Cohen S A, Trikha M, Mascelli M A. Potential future clinical applications for the GPIIb/IIIa antagonist, abciximab in thrombosis, vascular and oncological indications [J]. Pathol Oncol Res, 2000, 6(3):163-74.
[17]HoTinNoé B, Goerge T, Cifuni S M, et al. Platelet granule secretion continuously prevents intratumor hemorrhage[J]. Cancer Res, 2008, 68(16):6851-8.
[18]Appelmann I, Liersch R, Kessler T, et al. Angiogenesis inhibition in cancer therapy: plateletderived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy[J]. Recent Results Cancer Res, 2010, 180:51-81.
[19]Kaushansky K. Historical review: megakaryopoiesis and thrombopoiesis[J]. Blood, 2008, 111(3): 981-6.
[20]Schito L, Rey S, Tafani M, et al. Hypoxiainducible factor 1dependent expression of plateletderived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells[J]. Proc Natl Acad Sci USA, 2012, 109(40):E2707-16.
[21]Guo R R, Liu Y, Lu W L, et al. A recombinant peptide, hirudin, potentiates the inhibitory effects of stealthy liposomal vinblastine on the growth and metastasis of melanoma[J]. Biol Pharm Bull, 2008, 31(4):696-702.
[22]Coppinger J A, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions[J]. Blood, 2004, 103(6): 2096-104.
[22]韦忠红,汪思亮,盛晓波,等.出芽式肿瘤血管生成的分子调控机制[J].中国药理学通报,2013,29(9):1196-200.
[23]Wei Z H, Wang S L, Sheng X B, et al. Molecule regulation mechanism of tumor sprouting angiogenesis[J]. Chin Pharmacol Bull, 2013, 29(9): 1196-200.
[24]Mhle R, Green D, Moore M A, et al. Constitutive production and thrombininduced release of vascular endothelial growth factor by human megakaryocytes and platelets[J]. Proceed Nat Acad Sci, 1997, 94(2): 663-8.
[25]RadziwonBalicka A, SantosMartinez M J, Corbalan J J, et al. Mechanisms of plateletstimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPKMMP9 pathways[J]. Carcinogenesis, 2014, 35(2):324-32.
[26]Speich H E, Bhal V, Houser K H, et al. Signaling via P2Y12 may be critical for early stabilization of platelet aggregates[J]. J Cardiovasc Pharmacol, 2014, 63(6): 520-7.
[27]Semenza G L. HIF1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations[J]. J Clin Invest, 2013, 123(9): 3664-71.
[28]Semenza G L. HIF1: upstream and downstream of cancer metabolism[J]. Curr Opin Genet Dev, 2010, 20(1): 51-6.
[30]Shen K, Ji L, Gong C, et al. Notoginsenoside Ft1 promotes angiogenesis via HIF1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways[J]. Biochem Pharmacol, 2012, 84(6): 784-92.
[30]Ahn G O, Seita J, Hong B J, et al. Transcriptional activation of hypoxiainducible factor1 (HIF1) in myeloid cells promotes angiogenesis through VEGF and S100A8[J]. Proc Natl Acad Sci USA, 2014, 111(7):2698-703.
[31]Zhang H, Wong C C, Wei H, et al. HIF1dependent expression of angiopoietinlike 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs[J]. Oncogene, 2012, 31(14): 1757-70.
[32]Borsig L. Antimetastatic activities of modified heparins: selectin inhibition by heparin attenuates metastasis[J]. Semin Thromb Hemost, 2007, 33(5):540-6.
[33]Ferrández A, Piazuelo E, Castells A. Aspirin and the prevention of colorectal cancer[J]. Best Pract Res Clin Gastroenterol, 2012, 26(2):185-95.
[34]刘兆国,范方田,韦忠红,等.BRAF突变的黑色素瘤耐药机制研究进展[J]. 中国药理学通报,2013,29(10):1349-51.
[34]Liu Z G, Fan F T, Wei Z H, et al. Research progress of the mechanisms for drug resistance in melanoma with BRAFmutation[J]. Chin Pharmacol Bull, 2013, 29(10):1349-51.

相似文献/References:

[1]管斯斯,齐若梅,姜秀新,等.硝普钠对增龄机体血小板功能影响的研究[J].中国药理学通报,2008,(11):0.
 GUAN Si si,QI Ruo mei,JIANG Xiu xin,et al.Effects of sodium nitroprusside on platelet function in ageing[J].Chinese Pharmacological Bulletin,2008,(02):0.
[2]闫琰,赵革新,陈北冬,等.银杏内酯B抑制血小板CD40Ligand表达的分子机制研究[J].中国药理学通报,2012,(02):245.
 YAN Yan,ZHAO Ge xin,CHEN Bei dong,et al.Inhibitory effects of ginkgolide B on CD40 Ligand expression in collageninduced platelet activation[J].Chinese Pharmacological Bulletin,2012,(02):245.
[3]仲金秋,曹玉珠,沈培亮,等.血小板RNA与肿瘤[J].中国药理学通报,2017,(04):461.[doi:10.3969/j.issn.1001-1978.2017.04.004]
 ZHONG Jin-qiu,CAO Yu-zhu,SHEN Pei-liang,et al.Platelet RNA and cancer[J].Chinese Pharmacological Bulletin,2017,(02):461.[doi:10.3969/j.issn.1001-1978.2017.04.004]
[4]宋 伟,明章银.血小板在静脉血栓形成及诊断中的作用研究进展[J].中国药理学通报,2017,(07):889.[doi:10.3969/j.issn.1001-1978.2017.07.001]
 SONG Wei,MING Zhang-yin.Research progress on role of platelets in development and diagnosis of venous thrombosis[J].Chinese Pharmacological Bulletin,2017,(02):889.[doi:10.3969/j.issn.1001-1978.2017.07.001]
[5]王爱云,曹玉珠,韦忠红,等.血小板促进肿瘤生长与转移机制研究进展[J].中国药理学通报,2018,(08):1045.[doi:10.3969/j.issn.1001-1978.2018.08.003]
 WANG Ai-yun,CAO Yu-zhu,WEI Zhong-hong,et al.Platelets promoting tumor growth and metastasis[J].Chinese Pharmacological Bulletin,2018,(02):1045.[doi:10.3969/j.issn.1001-1978.2018.08.003]

备注/Memo

备注/Memo:
收稿日期:2014-11-03,修回日期:2014-12-10 基金项目:国家自然科学基金资助项目(No 81173174,81202655);教育部博士点基金资助项目(No 20113237110008);江苏省普通高校研究生科研创新计划项目(No KYLX_0972, KYZZ_0270) 作者简介:曹玉珠(1989-),女,硕士生,研究方向:肿瘤药物治疗及其机制,Email:576438252@qq.com; 陆茵(1963-),女,博士,教授,博士生导师,研究方向:活血化瘀中药及其复方抗肿瘤血管生成及对肿瘤转移、肿瘤微环境的影响,通讯作者,Tel:02585811239, Email:luyingreen@126.com
更新日期/Last Update: 1900-01-01