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Research progress on the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms
1.南京中医药大学药学院,江苏 南京210023;2.江苏省中药药效与安全性评价重点实验室,江苏 南京210023
CAO Yuzhu1 LIU Zhaoguo1 SHAN Yunlong1 SUN Lihua1 LIU Yuping1 WEI Zhonghong1 ZHU Pinting1 WU Hongyan1 WANG Aiyun1 CHEN Wenxing1ZHENG Shizhong12 LU Yin12
1.College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing210023, China; 2.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medicine,Nanjing210023, China
platelet tumor embolus tumor hematogenous spread molecular mechanisms therapy strategies clinical application
Tumor metastasis is one of the most important biological characteristics of malignant tumor, and it is also the main factors that cause treatment failure and poor prognosis. Clinical studies have shown that the number of platelets in patients with malignant tumor increased more significantly than that in benign tumor patients and healthy people, which indicate that platelet might be involved in the development process of tumor. Further study found that in the process of cancer spreading to blood, platelet could interact with tumor cells to form tumor emboli, helped tumor cells escape from immune surveillance, thus promoted the tumor metastasis. In recent years, related mechanisms on platelets in promoting tumor metastasis were revealed gradually, and several targeted therapies based on platelets were also carried out. This paper reviews the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms and discusses the therapy strategies that target platelet, which may provide references for followup research and clinical treatment.


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收稿日期:2014-11-03,修回日期:2014-12-10 基金项目:国家自然科学基金资助项目(No 81173174,81202655);教育部博士点基金资助项目(No 20113237110008);江苏省普通高校研究生科研创新计划项目(No KYLX_0972, KYZZ_0270) 作者简介:曹玉珠(1989-),女,硕士生,研究方向:肿瘤药物治疗及其机制,Email:576438252@qq.com; 陆茵(1963-),女,博士,教授,博士生导师,研究方向:活血化瘀中药及其复方抗肿瘤血管生成及对肿瘤转移、肿瘤微环境的影响,通讯作者,Tel:02585811239, Email:luyingreen@126.com
更新日期/Last Update: 1900-01-01