[1]邓 婕,李怡芳,栗原博,等.线粒体损伤与修复在帕金森病中的作用[J].中国药理学通报,2015,(07):906-909.[doi:10.3969/j.issn.1001-1978.2015.07.004]
 DENG Jie,LI Yi-fang,Hiroshi Kurihara,et al.Role of mitochondrial damage and repair in Parkinson's disease[J].Chinese Pharmacological Bulletin,2015,(07):906-909.[doi:10.3969/j.issn.1001-1978.2015.07.004]
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线粒体损伤与修复在帕金森病中的作用()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2015年07期
页码:
906-909
栏目:
讲座与综述
出版日期:
2015-07-15

文章信息/Info

Title:
Role of mitochondrial damage and repair in Parkinson's disease
作者:
邓 婕李怡芳栗原博何蓉蓉
暨南大学抗应激健康研究中心,药学院,广东 广州 510632
Author(s):
DENG Jie LI Yi-fang Hiroshi Kurihara HE Rong-rong
School of Pharmacy, Anti-Stress Health Research Center,Jinan University,Guangzhou 510632,China
关键词:
帕金森病 线粒体损伤 线粒体自噬 Parkin PINK1 心磷脂 天然药物
Keywords:
PD mitochondrial damage mitophagy Parkin PINK1 cardiolipin natural medicine
分类号:
R-05; R329.24; R745.705
DOI:
10.3969/j.issn.1001-1978.2015.07.004
文献标志码:
A
摘要:
帕金森病(Parkinson's disease,PD)是一种常见的中枢神经系统疾病,目前尚无有效的治疗方法。PD产生的原因有很多,包括遗传、环境、衰老等,这些因素导致黑质多巴胺能神经元退变有一共同过程:线粒体损伤与修复。该文综述了引起多巴胺能神经元线粒体功能损伤的环境因素和遗传因素,简述了线粒体修复途径(如自噬)对PD的治疗作用,进而从线粒体保护的角度分析天然药物治疗PD的研究现状。
Abstract:
Parkinson's disease(PD)is a common disease in central nervous system, for which an effective treatment has yet to be found. The causes of PD include genetic, environmental, aging factors, etc. There is a common factor which can lead to the degeneration of dopaminergic neurons in the substantia: mitochondrial damage and repair. This paper has summarized the environmental and genetic factors that can cause mitochondrial damage in dopaminergic neurons, and outlined several mitochondrial repairing pathways(such as mitophagy)in the treatment of PD. It also analyzes the research situation of utilizing natural medicine in the therapy of PD from the perspective of the mitochondrial protection.

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备注/Memo

备注/Memo:
收稿日期:2015-03-11,修回日期:2015-04-14 基金项目:国家自然科学基金资助项目(No 81473115); 教育部新世纪人才项目(No NCET-12-0678) 作者简介:邓 婕(1991-),女,硕士生,研究方向:神经免疫药理学,Tel:020-85227791,E-mail:jnudengjie@163.com; 何蓉蓉(1983-),女,博士,副教授,博士生导师,研究方向:神经免疫药理学,通讯作者,Tel:020-85227791, E-mail:rongronghe@jnu.edu.cn
更新日期/Last Update: 1900-01-01