[1]董宪喆,胡 园,刘 屏,等.lncRNA作为竞争性内源RNA调控胃癌进程的研究进展[J].中国药理学通报,2016,(09):1185-1189.[doi:10.3969/j.issn.1001-1978.2016.09.001]
 DONG Xian-zhe,HU Yuan,LIU Ping,et al.The research progress of lncRNA as CeRNA in gastric cancer[J].Chinese Pharmacological Bulletin,2016,(09):1185-1189.[doi:10.3969/j.issn.1001-1978.2016.09.001]
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lncRNA作为竞争性内源RNA调控胃癌进程的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2016年09期
页码:
1185-1189
栏目:
综述与讲座
出版日期:
2016-09-15

文章信息/Info

Title:
The research progress of lncRNA as CeRNA in gastric cancer
文章编号:
1001-1978(2016)09-1185-05
作者:
董宪喆1胡 园1刘 屏1路玉盼12
1.中国人民解放军总医院临床药理研究室,北京 100853;
2.山西中医学院中药学院,山西 晋中 030600
Author(s):
DONG Xian-zhe1 HU Yuan1 LIU Ping1LU Yu-pan12
1.Dept of Clinical Pharmacology, General Hospital of PLA, Beijing 100853,China;
2,Dept of Chinese Medicine, Shanxi University of TCM,Jinzhong Shanxi 030600,China
关键词:
长链非编码RNA 竞争性内源RNA 胃癌 microRNAs miRNA反应元件 靶基因
Keywords:
long non-coding RNAs competing endogenous RNAs gastric cancer microRNA miRNA response elements target genes
分类号:
R-05;R342.2;R394;R735.2
DOI:
10.3969/j.issn.1001-1978.2016.09.001
文献标志码:
A
摘要:
长链非编码RNA(long non-coding RNAs, lncRNAs)是一类长度大于200 nt的非编码RNA,参与多种疾病进程。近年来的研究表明,lncRNAs可作为竞争性内源RNA(competing endogenous RNAs,ceRNAs),与胃癌发生发展进程密切相关的驱动基因竞争miRNA反应元件(miRNA response elements,MREs),削弱miRNA对靶基因的抑制作用,间接调节靶基因表达水平,进而参与调控胃癌进程。该文从lncRNA作为ceRNA发挥生物学功能的角度,概述了相关lnRNAs在胃癌发生发展进程中的作用及机制,为胃癌的诊断和治疗提供新思路。
Abstract:
Recent studies have showed that RNAs regulate each other with microRNA(miRNA)response elements(MREs), and this mechanism is known as “competing endogenous RNA(ceRNA)” hypothesis. Long noncoding RNAs(lncRNAs)are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of lncRNAs has been found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that lncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several lncRNAs such as GAPLINC, BC032469,H19, HOTAIR, FER1L4 and MEG3 have been found to be associated with miRNAs in gastric cancer(GC). It is tempting to speculate that a multitude of lncRNAs may interrupt definitive steps in GC suppressive and oncogenic pathways. The uncovering of the underlying mechanisms of lncRNAs may benefit our understanding of gastric cancer's pathogenesis.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(No 81302909)
作者简介:董宪喆(1986-),女,博士生,助理研究员,研究方向:肿瘤和神经药理学,E-mail:dongxianzhe@163.com;
刘 屏(1956-),女,博士,研究员,研究方向:肿瘤和神经药理学,通讯作者,E-mail:liuping301@126.com
更新日期/Last Update: 2016-09-15