[1]邓 鋆,张 旭,喻珊珊.HIF-1α和 HIF-2α在低氧性肺动脉高压中的不同作用研究进展[J].中国药理学通报,2017,(01):10-13.[doi:10.3969/j.issn.1001-1978.2017.01.002]
 DENG Jun,ZHANG Xu,YU Shan-shan.Advances in differential roles of HIF-1α and HIF-2α in the pathogenesis of hypoxic pulmonary hypertension[J].Chinese Pharmacological Bulletin,2017,(01):10-13.[doi:10.3969/j.issn.1001-1978.2017.01.002]
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HIF-1α和 HIF-2α在低氧性肺动脉高压中的不同作用研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2017年01期
页码:
10-13
栏目:
讲座与综述
出版日期:
2017-01-15

文章信息/Info

Title:
Advances in differential roles of HIF-1α and HIF-2α in the pathogenesis of hypoxic pulmonary hypertension
文章编号:
1001-1978(2017)01-0010-04
作者:
邓 鋆1张 旭2喻珊珊1
1.南方医科大学珠江医院药剂科,广东 广州 510282;
2.广东省心血管病研究所广东省人民医院广东省医学科学院心儿科,广东 广州 510100
Author(s):
DENG Jun1ZHANG Xu2YU Shan-shan1
1.Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;
2.Guangdong Provincial Academy of Medicine,Guangdong General Hospital,Guangdong Provincial Cardiovascular Institute,Guangzhou 510100,China
关键词:
低氧诱导因子-1α 低氧诱导因子-2α 低氧 低氧性肺动脉高压 调控 功能
Keywords:
HIF-1α HIF-2α hypoxia hypoxic pulmonary hypertension regulation function
分类号:
R-05;R544.022;R845. 022;R977.6
DOI:
10.3969/j.issn.1001-1978.2017.01.002
文献标志码:
A
摘要:
低氧诱导因子家族(HIFs)是机体应对低氧环境时的主要调节因子,它们与低氧引起的肺组织细胞损伤以及异常增殖有关,其中又以低氧诱导因子-1α(HIF-1α)和低氧诱导因子-2α(HIF-2α)的作用最为明显。该文主要对HIF-1α、HIF-2α在结构功能上的异同和在低氧性肺动脉高压中作用的研究现状作一综述。
Abstract:
Hypoxia-induced factors(HIFs)are the main regulators for the response of hypoxic environment. They are involved in hypoxia-related lung tissue cell damage and abnormal cell proliferation, among which, HIF-1α and HIF-2α play the most improminant roles. This paper reviews the current researches of HIF-1α and HIF-2α, focusing on their structural and functional similarities and diversities, as well as their roles in the pathogenesis of hypoxic pulmonary hypertension.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(No 81200043,81000078);广东省自然科学基金项目(No S2013040014251)
作者简介:邓 鋆(1992-),男,硕士生,研究方向:心血管药理学,E-mail:dj2210920@163.com;
喻珊珊(1984-),女,博士,副主任药师,研究方向:心血管药理学、临床药学,通讯作者,E-mail:hygeia1019@163.com
更新日期/Last Update: 2017-01-15