[1]张世蘋,张 旭.Wnt信号通路在肿瘤调控方面的研究进展[J].中国药理学通报,2017,(01):14-18.[doi:10.3969/j.issn.1001-1978.2017.01.003]
 ZHANG Shi-ping,ZHANG Xu.Research progress on role of Wnt signaling pathway in regulation of tumors[J].Chinese Pharmacological Bulletin,2017,(01):14-18.[doi:10.3969/j.issn.1001-1978.2017.01.003]
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Wnt信号通路在肿瘤调控方面的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2017年01期
页码:
14-18
栏目:
讲座与综述
出版日期:
2017-01-15

文章信息/Info

Title:
Research progress on role of Wnt signaling pathway in regulation of tumors
文章编号:
1001-1978(2017)01-0014-05
作者:
张世蘋张 旭
南京中医药大学, 江苏省中医药防治肿瘤协同创新中心,江苏 南京 210023
Author(s):
ZHANG Shi-ping ZHANG Xu
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM)Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine,Nanjing 210023
关键词:
Wnt信号通路 β-catenin APC蛋白 信号通路的调节 机制 肿瘤
Keywords:
Wnt signaling pathway β-catenin Adenomatous polyposis coli protein regulation of signaling pathway mechanism tumor
分类号:
R-05;R329.2;R341;R73;R977.6
DOI:
10.3969/j.issn.1001-1978.2017.01.003
文献标志码:
A
摘要:
Wnt信号通路是一条进化上十分保守的信号通路,控制着细胞的生长、分化、凋亡和自我更新。在肿瘤的发生发展中,该通路常常异常激活,并能够和其他信号通路协同或拮抗调节肿瘤的增殖、迁移和侵袭。该文主要对Wnt信号通路的研究进展及其在各类肿瘤生长调控中的作用进行简要综述。
Abstract:
Wnt signaling pathway is a highly conservative signal pathway controlling cell growth, differentiation, apoptosis and self-renewal. This signal pathway is often abnormally activated in tumor development and progression, which can cooperate or antagonize with other signal pathways to regulate tumor proliferation, migration and invasion. This paper makes a review of the recent research of Wnt signaling pathway progression and its function in tumor growth regulation.

参考文献/References:

[1] Nusse R, Brown A, Papkoff J, et al. A new nomenclature for int-1 and related genes: the Wnt gene family[J]. Cell, 1991, 64(2): 231.
[2] Berndt J D,Moon R T. Cell biology. Making a point with Wnt signals[J].Science, 2013, 339(6126):1388-9.
[3] Nusse R. Wnt signaling in disease and in development[J]. Cell Res, 2005,15(1):28-32.
[4] Tao Q,Yokota C,Puck H, et al.Matemal Wnt 1 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos[J]. Cell, 2005, 120(6):857-71.
[5] Kikuchi A, Yamamoto H, Sato A, et al. New insights into the mechanism of Wnt signaling pathway activation[J]. Int Rev Cell Mol Biol,2011,291:21-71.
[6] Gan X Q, Wang J Y, Xi Y, et al. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction[J]. J Cell Biol,2008,180:1087-100.
[7] Xu H T,Wei Q,Liu Y, et al.Overexpression of axin downregulates TCF-4 and inhibits the development of lung cancer[J]. Ann Surg Oncol, 2007,14(11):3251-9.
[8] Grote H J,Schmiemann V,Kiel S,et al.Aberrant methylation of the adenomatous polyposis coli promoter IA in bronchial aspirates from patients with suspected lung cancer[J]. Int J Cancer,2004,110(5):751-5.
[9] Kim J C, Koo K H, Roh S A, et al. Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma[J]. Int J Colorectal Dis, 2003, 18(3):203-9.
[10] Niu C C,Zhao C,Yang Z D,et al. Down -regulation of γ-catenin inhibits CML cell growth and potentiates the response of CM L cells to imatinib through β-catenin inhibition[J]. Int J Mol Med,2013,31(2):453-8.
[11] Kim K A, Zhao J, Andarmani S, et al. R-Spondin proteins: a novel link to beta-catenin activation[J]. Cell Cycle ,2006,5:23-6.
[12] Hao H X, Xie Y, Zhang Y, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner[J]. Nature,2012,485:195-200.
[13] Duan L,Yao J,Wu X,et al. Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells[J].Biol Cell,2006, 98(8):479-90.
[14] Fre S, Pallavi S K, Huyghe M, et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine[J]. Proc Natl Acad Sci USA, 2009, 106(15):6309-14.
[15] Edlund S, Lee S Y, Grimsby S, et al. Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta induced apoptosis[J]. Mol Cell Biol, 2005,25:1475-88.
[16] Tang Y, Liu Z, Zhao L, et al. Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion[J]. J Biol Chem, 2008,283:23956-63.
[17] Heallen T, Zhang M, Wang J, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size[J]. Science, 2011, 332(6028):458-61.
[18] Azzolin L, Panciera T, Soligo S, et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response[J]. Cell, 2014, 158(1):157-70.
[19] Liao X, Siu M K, Au C W, et al. Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin[J]. Mod Pathol, 2009,22:839-47.
[20] Noubissi F K, Goswami S, Sanek N A, et al. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA[J]. Cancer Res, 2009,69:8572-8.
[21] 郭颖,田芝瑜,符航,等. 青篙琥酯诱导人结肠癌细胞凋亡与Wnt/β-catenin信号通路的关系研究[J].中国药理学通报,2016,32(5):707-11.
[21] Guo Y, Tian Z Y, Fu H, et al. Study on the relationship between promoting apoptosis effect of artesunate and Wnt/β-catenin pathway in colon cancer cells[J]. Chin Pharmacol Bull, 2016,32(5):707-11.
[22] 袁霜雪,王东旭,伍秋香,等. 白藜芦醇抑制HCT116结肠癌细胞增殖与Wnt/β-catenin的关系研究[J]. 中国药理学通报,2015,31(4):537-41.
[22] Yuan S X, Wang D X, Wu Q X, et al. Study on the relationship between anti-proliferation effect of resveratrol on HCT116 colon cancer cells and Wnt/β-catenin[J]. Chin Pharmacol Bull,2015,31(4):537-41.
[23] Tien L T,Ito M,Nakao M,et al.Expression of beta-catenin in hepatocellular carcinoma[J].World J Gastmenteml, 2005, 11(16):2398-401.
[24] Pacheco-Pinedo E C,Durham A C, Stewart K M,et al. Wnt /β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium[ J]. J Clin Invest,2011,121(5):1935-45.
[25] Farago M,Dominguez I,Landesman-Bollag E,et al. Kinase inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis[J]. Cancer Res,2005,65(13):5792-801.
[26] Malgor R,Crouser S,Greco D,et al.Correlation of Wnt5a expression with histopathological grade/stage in urothelial carcinoma of the bladder[J]. Diagn Pathol,2013,8:139.
[27] Du Y,Wang Y,Zhang F,et al. Regulation of metastasis of bladder cancer cells through the Wnt signaling pathway[J].Tumour Biol,2015,36(11):8839-44.
[28] Ma L,Zhang G,Miao X B,et al. Cancer stem -like cell properties are regulated by EGFR/AKT/beta-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma[J]. FEBS J,2013,280(9): 2027-41.
[29] Zhang P,Wu S K,Wang Y,et al.p53,MDM2,eIF4E and EGFR expression in nasopharyngeal carcinoma and their correlation with clinicopathological characteristics and prognosis: a retrospective study[J].Oncol Lett,2015,9(1): 113-8.
[30] Weeraratna A T,Jiang Y,Hostetter G,et al.Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma[J].Cancer Cell, 2002,1(3):279-88.

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备注/Memo

备注/Memo:
基金项目: 江苏省2015年度普通高校研究生科研创新计划项目(No KYZZ15-0274);The People Programme(Marie Curie Actions)of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement n° PIR SES-GA -2013-612589);江苏省优势学科和江苏省自然科学基金项目(No BK20131415);国家自然科学基金资助项目(No 81503374)
作者简介:张世蘋(1982-),女,博士生,研究方向:中药复方抗肿瘤,Tel:025-85811813, E-mail:apple17_guoguo@126.com;
张 旭(1968-),女,博士,教授,研究方向:中药复方抗肿瘤,通讯作者,E-mail:zhangxu@njutcm.edu.cn
更新日期/Last Update: 2017-01-15