[1]仲金秋,曹玉珠,沈培亮,等.血小板RNA与肿瘤[J].中国药理学通报,2017,(04):461-464.[doi:10.3969/j.issn.1001-1978.2017.04.004]
 ZHONG Jin-qiu,CAO Yu-zhu,SHEN Pei-liang,et al.Platelet RNA and cancer[J].Chinese Pharmacological Bulletin,2017,(04):461-464.[doi:10.3969/j.issn.1001-1978.2017.04.004]
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血小板RNA与肿瘤()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2017年04期
页码:
461-464
栏目:
讲座与综述
出版日期:
2017-04-15

文章信息/Info

Title:
Platelet RNA and cancer
文章编号:
1001-1978(2017)04-0461-04
作者:
仲金秋1曹玉珠1沈培亮1张婷婷1王爱云12 陈文星12陆 茵12
1.南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室,江苏 南京 210023;
2.南京中医药大学 江苏省中医药防治肿瘤协同创新中心,江苏 南京 210023
Author(s):
ZHONG Jin-qiu1 CAO Yu-zhu1 SHEN Pei-liang1ZHANG Ting-ting1 WANG Ai-yun12 CHEN Wen-xing12 LU Yin12
1.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine, Nanjing 210023, China;
2.Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM)Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine,Nanjing 210023,China
关键词:
血小板 肿瘤 RNA 微囊泡 内皮细胞 液体活检
Keywords:
platelets tumor RNA microvesicles endothelial cells liquid biopsy
分类号:
R-05;R331.124;R342.2;R730.2;R730.4
DOI:
10.3969/j.issn.1001-1978.2017.04.004
文献标志码:
A
摘要:
血小板是人体中重要的无核血细胞,生理状态下主要发挥止血和促进伤口愈合的作用。此外,血小板也参与了多种病理过程,主要包括炎症、血管生成、组织再生以及肿瘤的恶性发展等。目前,大量研究显示血小板在肿瘤发生发展中发挥着极其重要的作用,并且参与了肿瘤发生发展的多个过程。最新的研究证明肿瘤微环境中血小板RNA水平发生明显改变并且影响着肿瘤的发展进程。该文综述了近几年报道的在肿瘤微环境中肿瘤细胞对血小板RNA影响及其可能产生的病理效应的相关研究。为临床肿瘤检测以及基于RNA进行血小板与肿瘤之间交互作用的研究提供一定指导。
Abstract:
Platelets are anucleate blood cells best known for their role in hemostasis and wound healing. In addition to hemostasis, platelets are involved in a variety of pathophysiological responses including immune inflammation, angiogenesis, tissue regeneration, and cancer metastasis, and participate in multiple process of tumor development. Recent studies have shown that tumor microenvironment affects the state of RNA in platelets and biology of downstream. This review will focus on our understanding of the possible influence of tumor microenvironment on platelet RNA and the pathological effect, and how this knowledge can guide the development of the interaction between platelets and tumor for clinical application.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目资助(No 81403260,81573859,81673725,81673648),中国博士后科学基金(No 2014M551639),江苏省博士后项目(1401138C),2013年江苏高校优秀科技创新团队计划[苏教科(2013)10号文],江苏高校品牌专业建设工程资助项目PPZY2015A070, 江苏高校中药学优势学科建设工程资助项目(PAPD)[苏政办发(2014)37号文]。江苏省普通高校研究生科研创新计划项目(KYZZ15_0271, KYLX_0972)
作者简介:仲金秋(1994-),女,硕士生,研究方向:活血化瘀中药对血小板介导肿瘤血行转移的整合效应研究,E-mail:ladymagnolia@163.com; 王爱云(1974-),女,副教授,硕士生导师,研究方向:活血化瘀中药对肿瘤转移的影响,通讯作者,Tel:025-85811237,E-mail:way9815@163.com
更新日期/Last Update: 2017-04-15