[1]李汉清,可 燕.上皮间质转化的机制研究进展[J].中国药理学通报,2017,(10):1342-1344.[doi:10.3969/j.issn.1001-1978.2017.10.003]
 LI Han-qing,KE yan.Mechanism of epithelial-mesenchymal transition[J].Chinese Pharmacological Bulletin,2017,(10):1342-1344.[doi:10.3969/j.issn.1001-1978.2017.10.003]
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上皮间质转化的机制研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2017年10期
页码:
1342-1344
栏目:
讲座与综述
出版日期:
2017-09-20

文章信息/Info

Title:
Mechanism of epithelial-mesenchymal transition
文章编号:
1001-1978(2017)10-1342-03
作者:
李汉清可 燕
上海中医药大学教学实验中心,上海 201203
Author(s):
LI Han-qing KE yan
Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
关键词:
上皮间质转化 转录因子 生长因子 蛋白分子 分子机制 天然化合物
Keywords:
epithelial-mesenchymal transition transcription factor growth factor protein molecule molecular mechanism natural compound
分类号:
R-05;R284.1;R329.24;R394
DOI:
10.3969/j.issn.1001-1978.2017.10.003
文献标志码:
A
摘要:
上皮间质转化(epithelial-mesenchymal transition,EMT)是上皮细胞转化为能动的间质细胞的过程,在胚胎发育、创伤愈合、器官纤维化、肿瘤发生发展中均发挥着重要作用。它的发生与多种转录因子、蛋白分子及生长因子等相关,其中涉及到复杂的分子机制和信号转导通路。该文主要对EMT的调节机制做一综述,并简要概括了以EMT为靶向的天然化合物的研究进展。
Abstract:
Epithelial-mesenchymal transition(EMT)is a process by which the epithelial cells change to a mesenchymal phenotype. The highly conserved and fundamental process is integral in development, wound healing and contributes pathologically to fibrosis and cancer progression. The process can be activated by many transcription factors, growth factors or protein molecules, which involves complex molecular mechanism and signal transduction pathways. This paper reviews the development of molecular mechanisms of epithelial–mesenchymal transition and briefly summarizes the research progress of natural compounds targeting the EMT.

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备注/Memo

备注/Memo:
基金项目:上海市卫生局课题(No 20144Y0152); 上海市教委预算内课题(No 2015YSN25)
作者简介:李汉清(1990-),男,硕士生,研究方向:中药活性成分筛选,E-mail:13127516810@163.com;
可 燕(1969-),女,博士,教授,硕士生导师,研究方向:中药活性成分筛选,通讯作者,Tel:021-51322539,E-mail: keyantcm@163.com
更新日期/Last Update: 2017-09-20