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Advances in matrix metalloproteinase 13 in cartilage remodeling and arthritis
范凯健12吴 菁1李 钦1王婷玉1
1.上海交通大学医学院附属第九人民医院药剂科,上海 200011;
2.上海市宝山区中西医结合医院药剂科,上海 201901
FAN Kai-jian12 WU Jing1 LI Qin1 WANG Ting-yu1
1.Dept of Pharmacy, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China;
2.Dept of Pharmacy, Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201901, China
关节炎 基质金属蛋白酶13 Ⅱ型胶原 Runx2 分子靶标 表观调控
arthritis MMP-13 type II collagen Runx2 molecular target epigenetic
R-05; R322.72; R345.9; R684.3; R977.3
Arthritis is a common chronic disease characterized by the destruction of joint cartilage and inflammation in the surrounding tissues. Although it is known that the pathogenesis of arthritis is influenced by a series of factors, the underlying mechanisms remain unclarified. Recently, increasing attention has been paid to the increase of matrix metalloproteinases(MMPs)in articular cartilage, resulting in an inevitable degradation of cartilage and extracellular matrix(ECM). MMP-13, the major functioning enzyme during arthritis development, plays a vital role in the cartilage destruction, thus contributing to the decomposition of type II collagen irreversibly. A variety of cellular cytokines such as IL-1β and TNF-α, and Runx2 are assumed to affect the expression of MMP-13 in chondrocytes. The hypomethylation of the promoter region of the MMP-13 may induce its expression, while it can be reduced by inhibiting histone acetylation. Meanwhile, microRNA can reduce the expression of MMP-13. In conclusion, MMP-13 can be used as an important therapeutic target in arthritis. In this review, we focus on the role of MMP-13 in arthritis and its underlying regulatory mechanisms.


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基金项目:国家自然科学基金资助项目(No 81301531, 81572104)
作者简介:范凯健(1988 -),男,硕士生,研究方向:药理学,E-mail: fankaijian2017@163.com;
王婷玉(1982 -),女,博士,副主任药师,硕士生导师,研究方向:药理学、临床药学,通讯作者,E-mail: drtywang@163.com
更新日期/Last Update: 2018-04-25