[1]黄秀旺,许建华,吴国华,等.姜黄素固体分散体在小鼠体内的药代动力学[J].中国药理学通报,2008,(11):0.
 HUANG Xiu wang,XU Jian hua,WU Guo hua,et al.Pharmacokinetics of curcumin solid dispersion in mice[J].Chinese Pharmacological Bulletin,2008,(11):0.
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姜黄素固体分散体在小鼠体内的药代动力学()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2008年11期
页码:
0
栏目:
论著
出版日期:
2008-11-25

文章信息/Info

Title:
Pharmacokinetics of curcumin solid dispersion in mice
作者:
黄秀旺1许建华1吴国华2温彩霞1
福建医科大学药学院1.临床药理研究所,2.药学实验教学中心,福建 福州350004
Author(s):
HUANG Xiuwang1XU Jianhua1WU Guohua2WEN Caixia1
1.Institute of Clinical Pharmacology;2.Teaching Center of Pharmaceutical Laboratory,Dep of Pharmacology,Fujian Medical University,Fuzhou350004,China
关键词:
姜黄素药代动力学高效液相色谱固体分散体
Keywords:
curcuminpharmacokineticsHPLCsolid dispersion
分类号:
R332;R 28271;R 452;R 4461;R 944;R 9691
文献标志码:
A
摘要:
目的以姜黄素混悬液为对照,研究姜黄素-聚维酮固体分散体灌胃给药后在小鼠体内的药代动力学。方法按300 mg·kg-1的剂量小鼠灌胃姜黄素固体分散体溶液或姜黄素混悬液,采用高效液相色谱法测定血浆中姜黄素含量,用DAS软件拟合房室模型,计算药动学参数。并测定了给药3 h时药物的吸收率。结果姜黄素-聚维酮固体分散体在小鼠体内的药代动力学符合二室开放模型,主要药动学参数如下: T12α和T12β分别为164和266 min,AUC为896 mg·L-1·min-1,Vd为7639 L,V1为510 L,CL为199 L·min-1。姜黄素-聚维酮固体分散体在胃肠道的吸收率是姜黄素混悬液的675倍。结论姜黄素固体分散体灌胃可显著增加姜黄素的生物利用度,血药浓度较高。
Abstract:
AimTo study the pharmacokinetics of curcuminpvp solid dispersion ig administration in mice in comparison with the free curcumin suspension.MethodsDrugs were administered at a dose of 300 mg·kg-1 via ig.The plasma concentration of curcumin was determined by HPLC,the pharmacokinetics were calculated by DAS ver10 program.ResultsThe curcumin pharmacokinetics conforms to a twocompartment open model after a single ig dose of curcumin solid dispersion in mice.The parameters were as follows:T12α and T12β were 164 and 2661 min,respectively.AUC was 896 mg·L-1·min-1,Vd was 7639 L,V1 was 510 L,and CL was 199 L·min-1.The absorption rate of curcumin solid dispersion was 675 times as much as curcumin suspension.ConclusionThe curcumin solid dispersion improves the absorption of curcumin in vivo in mice evidently.

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备注/Memo

备注/Memo:
收稿日期:2008-07-03,修回日期:2008-09-13基金项目:福建省重大专项前期研究项目资助项目(No 2005YZ1010)作者简介:黄秀旺(1963-),男,助理研究员,研究方向:体内药物分析,Tel/Fax:059183569307,Email:xwh705@126.com;许建华(1958-),男,教授,博士生导师,研究方向:肿瘤药理学,通讯作者,Tel/Fax:059183569307,Email:xjh@mail.fjmu.edu.cn
更新日期/Last Update: 2008-11-15