[1]熊飞,詹瑧,唐于平,等.PI3K/Akt信号转导通路在非小细胞肺癌中的作用[J].中国药理学通报,2010,(10):1264-1266.
 XIONG Fei,ZHAN Zhen,TANG Yu ping,et al.The effect of PI3K/Akt signal transduction pathway in nonsmall cell lung cancer[J].Chinese Pharmacological Bulletin,2010,(10):1264-1266.
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PI3K/Akt信号转导通路在非小细胞肺癌中的作用()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2010年10期
页码:
1264-1266
栏目:
讲座与综述
出版日期:
2010-10-25

文章信息/Info

Title:
The effect of PI3K/Akt signal transduction pathway in nonsmall cell lung cancer
作者:
熊飞1詹瑧1唐于平2段金廒2尹莲3张旭12
1.南京中医药大学基础医学院中西医结合基础学科,2.江苏省方剂研究重点实验室,3.南京中医药大学药学院,江苏 南京210046
Author(s):
XIONG Fei1ZHAN Zhen1TANG Yuping2DUAN Jinao2YIN Liao3ZHANG Xu12
1.The Preclinical Medicine College,Nanjing University of Chinese Medicine,2.Jiangsu Key Laboratory for TCM Formulae ResearchLTCMF,3.College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing210046,China
关键词:
肺癌NSCLCPI3K/Akt通路分子机制多靶点治疗
Keywords:
lung cancerNSCLCPI3K/Akt pathwaymolecular mechanismmultitargettherapy
分类号:
R05;R 32925;R 7342023
文献标志码:
A
摘要:
肺癌是当今世界严重威胁人类健康和生命的疾病,其中85%是非小细胞肺癌(NSCLC)。PI3K/Akt通路在NSCLC的发生、发展中具有重要的作用,可以调控细胞存活、增殖、抗凋亡、血管生成等影响肿瘤的发生发展,而且某些蛋白的表达还是NSCLC不良预后的标志。在此我们对PI3K/Akt通路在NSCLC中的分子机制进行总结,并进一步讨论NSCLC的多靶点治疗。
Abstract:
Lung cancer is the most threatening disease of the human health and life,and 85% of the disease is nonsmall cell lung cancer(NSCLC).The PI3K/Akt pathway plays an important role in NSCLC development,it can regulate cell survival,proliferation,antiapoptosis,angiogenesis,etc. And the expression of some of these proteins also identifies the poor prognosis of NSCLC. This article reviews the molecular mechanism of the PI3K/Akt pathway in NSCLC,and further discusses the potential multitargeted therapy for NSCLC.

参考文献/References:

[1]周宇辉,詹瑧,唐于平,等.丝裂原活化蛋白激酶信号通路在非小细胞肺癌中作用的研究进展[J].中国肺癌杂志,2009,12(9):1036-40.[1]Zhou Y H,Zhan Z,Tang Y P,et al.Advance on the role of mitogenactivated protein kinase(MAPK)signal pathway in nonsmall cell lung cancer[J].Chin J Lung Cancer,2009,12(9):1036-40.
[2]Chen C H,Lai J M,Chou T Y,et al.VEGFA Upregulates FLJ 10540 and modulates migration and invasion of lung cancer via PI3K/Akt pathway[J].PLoS ONE,2009,4(4):e5052.
[3]Schuurbiers O C,Kaanders J H,van der Heijden H F,et al.The PI3K/Aktpathway and radiation resistance mechanisms in nonsmall cell lung cancer[J].J Thorac Oncol,2009,4(6):761-7.
[4]Xiong X H,Fu L L,Wang L,et al.Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo[J].Invest New Drugs,2009,27:1-11.
[5]Zou Z Q,Zhang X H,Wang F,et al.A novel dual PI3K·/mTOR inhibitor PI103 with high antitumor activity in nonsmall cell lung cancer cells[J].Inter J Mol Med,2009,24:97-101.
[6]Ueda Y,Igishi T,Hashimoto K,et al.Synergistic cell growth inhibition by the combination of amrubicin and Aktsuppressing tyrosine kinase inhibitors in small cell lung cancer cells:Implication of cSrc and its inhibitor[J].International J Oncol,2009,342:689-96.
[7]Cho Y,Park M J,Park M,et al.Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in nonsmall cell lung cancer cells[J].Respirology,2009,14(6):850-8.
[8]孙焕,陆付耳,王增四,等.小檗碱改善高糖高脂诱导的胰岛NIT1细胞凋亡的分子机制[J].中国药理学通报,2008,24(6):762-6.
[8]Sun H,Lu F E,Wang Z S,et al.The molecular mechanism of Berberine improve NIT1 islet cell apoptosis induced by high glucose and fat[J].Chin Pharmacol Bull,2008,24(6):762-6.
[9]Magesh V,Lee J C,Ahn K S,et al.Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of lewis lung carcinoma cells[J].Phytother Res,2009,23(10):1385-91.
[10]Bao R,Lai C J,Wang D G,et al.Targeting heat shock protein 90 with CUDC305 overcomes erlotinib resistance in nonsmall cell lung cancer[J].Mol Cancer Ther,2009,8(12):3296-306.
[11]Matsuzaki H,Ichino A,Hayashi T,et al.Regulation of intracellular localizationand transcriptional activity of FOXO4 by proteinkinaseB through phosphorylation at the motif sites conserved among the FOXO family[J].J Biochem,2005,138:485-91.
[12]Maekawa T,Maniwa Y,Doi T,et al.Expression and localization of FOXO1 in nonsmall cell lung cancer[J].Oncol Rep,2009,22:57-64.
[13]Luo J L,Kamata H,Karin M.IKK/NFκB signaling:balancing life and deatha new approach to cancer therapy[J].Clin Invest,2005,115:2625-32.
[14]Lee D F,Kuo H P,Chen C T,et al.IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway[J].Cell,2007,130:440-55.
[15]Lin J C,Yang S C,Hong T M,et al.Phenanthrenebased tylophorine1(PBT1) inhibits lung cancer cell growth through the Akt and NF kappaB pathways[J].J Med Chem,2009,52(7):1903-11.
[16]Yan K H,Yao C J,Chang H Y,et al.The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells[J].Mol Carclnog,2010,49:235-46.
[17]Wislez M,Spencer M L,Izzo J G,et al.Inhibition of mammalian target of rapamycin reverse salveolar epithelialneo plasia induced by oncogenic Kras[J].Cancer Res,2006,65: 3226-35.
[18]Sun S Y,Fu H,Khuri F R.Targeting mTOR signaling for lung cancer therapy[J].Thorac Oncol,2006,1:109-11.
[19]Yuan R,Kay A,Berg W J,et al.Targeting tumorigenesis:development and use of mTOR inhibitors in cancer therapy[J].J Hematol Oncol,2009,2:45.
[20]Humar R,Kiefer F N,Berns H,et al.Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin(mTOR)dependent signaling[J].FASEB J,2002,16(8):771-80.
[21]Yan L,Lavin V A,Moser L R,et al.PP2A regulates the proapoptotic activity of FOXO1[J].J Biol Chem,2008,283:7411-20.
[22]Kumaraguruparan R,Karunagaran D,Balachandran C,et al.Of human andcanines:a comparative evaluation of heatshock and apoptosisassociated proteins in mammary tumours[J].Clin Chim Acta,2006,365(12):168-76.
[23]王芳,符立梧.多靶点抗肿瘤新药索拉非尼的研究进展[J].中国药理学通报,2008,24(8):1117-20.
[23]Wang F,Fu L W.Multitarget antitumor drug Sorafenib research progress[J].Chin Pharmacol Bull,2008,24(8):1117-20.

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备注/Memo

备注/Memo:
收稿日期:2010-05-27,修回日期:2010-07-18基金项目:国家科技支撑计划重点资助项目(No 2006BAI11B0801)作者简介:熊飞(1986-),男,硕士生,Email:xf123456.cool@163.com;张旭(1968-),女,博士,教授,博士生导师,通讯作者,Tel:02586798200,Email:zhangxutcm@gmail.com
更新日期/Last Update: 2011-01-27