HAN Dong,WANG Gui zuo,LI Man xiang.Role of AMPK in pulmonary diseases[J].Chinese Pharmacological Bulletin,2013,(04):460-463.





Role of AMPK in pulmonary diseases
西安交通大学医学院第二附属医院呼吸病研究室,呼吸内科, 陕西 西安710004
HAN Dong WANG GuizuoLI Manxiang
Institution of Respiratory Medicine, Dept of Respiratory Medicine, the Second Affiliated Hospital, Xi′an Jiaotong University College of Medicine, Xi′an710004, China
structure and function therapeutic effectlung cancerasthmaPAH
腺苷酸活化蛋白激酶(AMPactivated protein kinase,AMPK)是一种广泛参与人体内能量代谢活动的蛋白激酶。新近的研究发现,AMPK可调控多种疾病发生、发展过程中的病理环节。近年来,AMPK与肺部疾病的关系愈发受到人们的重视,目前研究认为AMPK对肺癌、支气管哮喘及肺动脉高压等肺部疾病的治疗具有潜在的作用。该文就AMPK的生物学特性及其对多种肺部疾病的潜在治疗作用进展做一综述。
AMPK is an important protein kinase, which controls/regulates the activity of energy metabolism in human body. Recent study has found that AMPK plays a critical role in the pathophysiological process of a variety of diseases. In recent years, the relationship between AMPK and pulmonary diseases has aroused extensive attention. Studies suggest that AMPK has a potential role in the treatment of pulmonary diseases such as lung cancer, asthma, acute lung injury, pulmonary hypertension and cystic fibrosis. This review summarizes the biological characteristics of AMPK and its potential therapeutic effect on such diseases.


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 HUANG Liang,WANG Han-qun,ZHANG Chi,et al.Neu-P11 protects against hypoxia/reoxygenation injury through AMPK activation in H9c2 myocardial cells[J].Chinese Pharmacological Bulletin,2014,(04):104.


收稿日期:2012-11-08,修回日期:2013-01-13 基金项目:国家自然科学基金资助项目(No 81070045) 作者简介:韩冬(1987-),男,博士生,研究方向:肺动脉高压及分子机制,Email:sesury@gmail.com; 李满祥(1966-),男,博士,教授,主任医师,博士生导师,研究方向:肺动脉高压的分子生物学基础及干预、支气管哮喘气道重塑的分子基础及治疗,通讯作者,Tel:02987679464,Email:manxiangli@hotmail.com
更新日期/Last Update: 2013-04-25