[1]周仁鹏,陈飞虎.酸敏感离子通道在类风湿关节炎中作用的研究进展[J].中国药理学通报,2015,(03):315-318.[doi:10.3969/j.issn.1001-1978.2015.03.005]
 ZHOU Ren-peng,CHEN Fei-hu.Research progress on role of acid-sensing ion channels in rheumatoid arthritis[J].Chinese Pharmacological Bulletin,2015,(03):315-318.[doi:10.3969/j.issn.1001-1978.2015.03.005]
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酸敏感离子通道在类风湿关节炎中作用的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2015年03期
页码:
315-318
栏目:
讲座与综述
出版日期:
2015-03-25

文章信息/Info

Title:
Research progress on role of acid-sensing ion channels in rheumatoid arthritis
作者:
周仁鹏陈飞虎
安徽医科大学药学院,安徽 合肥 230032
Author(s):
ZHOU Ren-pengCHEN Fei-hu
School of Pharmacy,Anhui Medical University,Hefei 230032,China
关键词:
酸敏感离子通道 类风湿关节炎 酸中毒 炎症 靶点
Keywords:
acid-sensing ion channels rheumatoid arthritis acidosis calcium inflammation therapeutic target
分类号:
R-05; R329.25; R593.22
DOI:
10.3969/j.issn.1001-1978.2015.03.005
文献标志码:
A
摘要:
酸敏感离子通道(acid-sensing ion channels, ASICs)是一类胞外H+激活的阳离子通道,属于阿米洛利敏感的上皮钠通道/退变素(epithelial Na+ channels/ degenerin, ENaC/DEG)超家族中的一员,该通道广泛分布在周围和中枢神经系统中,并且具有重要的生物学功能。近来研究表明,ASICs在类风湿关节炎发病过程中发挥着重要作用。该文对ASICs的细胞生物学特点以及ASICs在类风湿关节炎中对炎症、疼痛和软骨损伤等方面的作用进行综述。
Abstract:
Acid-sensing ion channels(ASICs)are cation channels activated by extracellular H+, which belong to the amiloride-sensitive epithelial Na+ channels/degenerin(ENaC/DEG)superfamily. These channels are widely expressed in the central and peripheral nervous systems and have crucial biological functions. Recent studies have demonstrated that ASICs play an important role in the pathogenesis of rheumatoid arthritis. This review concerns the cell biological characteristics of ASICs as well as its role in inflammation, pain, cartilage destruction and other aspects in rheumatoid arthritis.

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备注/Memo

备注/Memo:
收稿日期:2014-10-09,修回日期:2014-11-26 基金项目:国家自然科学基金资助项目(No 81271949,30873080); 高等学校博士学科点专项科研基金项目(No 20093420110005) 作者简介:周仁鹏(1987-),男,硕士生,研究方向:分子药理学,E-mail:zrpgujiu@163.com; 陈飞虎(1962-),男,博士,教授,博士生导师,研究方向:抗炎免疫药理学及分子药理学,通讯作者,Tel:0551-65161116,E-mail:cfhchina@sohu.com
更新日期/Last Update: 2015-03-25