NI Jie-ming,NI An-ping.Research progress of regulation mechanism of innate immunity in malaria[J].Chinese Pharmacological Bulletin,2018,(05):612-615.[doi:10.3969/j.issn.1001-1978.2018.05.006]





Research progress of regulation mechanism of innate immunity in malaria
1.中国医科大学,辽宁 沈阳 110122;
2.中国医学科学院北京协和医学院检验科,北京 100730
NI Jie-ming1 NI An-ping2
1.China Medical University, Shenyang 110122,China;
2.Dept of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
固有免疫 疟疾 巨噬细胞 单核细胞 树突状细胞 自然杀伤细胞 γδT细胞 自噬 靶向治疗
innate immunity malaria macrophage monocyte DC NK γδT cell autophagy targeted treatment
R-05; R329.24; R392.12; R531.303
Malaria is a kind of disease detrimental to human health and plasmodium is a critical pathogen in it. The immunity against foreign antigens including plasmodium could be divided into two categories, namely, adaptive immunity and innate immunity. Innate immunity induces non-specific immune response, and is composed of monocyte, macrophage, γδT cell, DC, NK, and cytokines etc. Innate immunity cooperates with adaptive immunity efficiently to protect against malaria. Meanwhile, autophagy is not only the cellular degrading process, but also gets involved in regulating immune system and defending against plasmodium infection. Therefore, elucidation of corresponding mechanism could provide proof for efficiently controlling and curing malaria, developing related medicine and vaccine, and clinical treatment as well. This article reviews the constitution of innate immunity in malaria, related regulation mechanism and relevant therapeutic targets for it.


[1] Richards S N, Nash M N, Baker E S, et al. Molecular mechanisms for drug hypersensitivity induced by the malaria parasite's chloroquine resistance transporter[J]. PLoS Pathog, 2016,12(7): e1005725.
[2] Farooq F, Bergmann-Leitner E S. Immune escape mechanisms are Plasmodium's secret weapons foiling the success of potent and persistently efficacious Malaria vaccines[J]. Clin Immunol, 2015,161(2): 136-43.
[3] Ng S, March S, Galstian A, et al. Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro[J]. Dis Model Mech, 2014,7(2): 215-24.
[4] 李赫宁,李兰芳, 陈临溪.内质网自噬——疾病防治的新靶标[J].中国药理学通报, 2015,31(3): 302-8.
[4] Li H N, Li L F, Chen L X. Reticulophagy—a new target for diseases prevention and treatment [J]. Chin Pharmacol Bull, 2015,31(3):302-8.
[5] Schumak B, Klocke K, Kuepper J M, et al. Specific depletion of Ly6C(hi)inflammatory monocytes prevents immunopathology in experimental cerebral malaria[J]. PLoS One, 2015,10(4): e0124080.
[6] Aubouy A, Olagnier D, Bertin G, et al. Nrf2-driven CD36 and HO-1 gene expression in circulating monocytes correlates with favourable clinical outcome in pregnancy-associated malaria[J]. Malar J, 2015, 14: 358.
[7] Antonelli L R, Leoratti F M, Costa P A, et al. The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria[J]. PLoS Pathog, 2014,10(9): e1004393.
[8] Wu X, Gowda N M, Gowda D C. Phagosomal acidification prevents macrophage inflammatory cytokine production to malaria, and dendritic cells are the major source at the early stages of infection: implication for malaria protective immunity development[J]. J Biol Chem, 2015, 290(38): 23135-47.
[9] Ayi K, Lu Z, Serghides L, et al. CD47-SIRPalpha interactions regulate macrophage uptake of plasmodium falciparum-infected erythrocytes and clearance of malaria in vivo[J]. Infect Immun, 2016, 84(7): 2002-11.
[10] Weinberg J B, Volkheimer A D, Rubach M P, et al. Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity[J]. Sci Rep, 2016, 6: 29151.
[11] Warimwe G M, Murungi L M, Kamuyu G, et al. The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children[J]. PLoS One, 2013, 8(2): e57320.
[12] Olagnier D, Lavergne R A, Meunier E, et al. Nrf2, a PPARgamma alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria[J]. PLoS Pathog, 2011, 7(9): e1002254.
[13] 魏 伟.炎症免疫反应软调节[J]. 中国药理学通报,2016,32(3): 297-303.
[13] Wei W. Soft regulation of inflammatory immune responses [J]. Chin Pharmacol Bull, 2016,32(3): 297-303.
[14] Hirako I C, Ataide M A, Faustino L, et al. Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria[J]. Nat Commun, 2016, 7: 13277.
[15] Loevenich K, Ueffing K, Abel S, et al. DC-derived IL-10 modulates pro-inflammatory cytokine production and promotes induction of CD4+IL-10+ regulatory T cells during Plasmodium yoelii infection[J]. Front Immunol, 2017, 8: 152.
[16] Spaulding E, Fooksman D, Moore J M, et al. STING-licensed macrophages prime type I IFN production by plasmacytoid dendritic cells in the bone marrow during severe Plasmodium yoelii malaria[J]. PLoS Pathog, 2016, 12(10): e1005975.
[17] Wykes M N. Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity[J]? Trends Parasitol, 2012, 28(5): 182-6.
[18] Yu X, Cai B, Wang M, et al. Cross-regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality[J]. Immunity, 2016, 45(5): 1093-107.
[19] McCall M B, Roestenberg M, Ploemen I, et al. Memory-like IFN-gamma response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum[J]. Eur J Immunol, 2010,40(12): 3472-7.
[20] Gowda N M, Wu X, Kumar S, et al. CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells[J]. PLoS One, 2013, 8(10): e77604.
[21] Ryg-Cornejo V, Nie C Q, Bernard N J, et al. NK cells and conventional dendritic cells engage in reciprocal activation for the induction of inflammatory responses during Plasmodium berghei ANKA infection[J]. Immunobiology, 2013, 218(2): 263-71.
[22] Li C, Mannoor K, Inafuku M, et al. Protective function of an unconventional gammadelta T cell subset against malaria infection in apoptosis inhibitor deficient mice[J]. Cell Immunol, 2012, 279(2): 151-9.
[23] Yu Y, Hou L, Song H, et al. Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells[J]. Mol Cell Biochem, 2017, 424(1-2): 173-83.
[24] Hong-Brown L Q, Brown C R, Navaratnarajah M, et al. FoxO1-AMPK-ULK1 regulates ethanol-induced autophagy in muscle by enhanced ATG14 association with the BECN1-PIK3C3 complex[J]. Alcohol Clin Exp Res, 2017, 41(5): 895-910.
[25] Hain A U, Bosch J. Autophagy in Plasmodium, a multifunctional pathway[J]? Comput Struct Biotechnol J, 2013, 8:e20130.


作者简介:倪杰明(1995-),男,七年制本科在读, E-mail:nijieming1995@163.com;
更新日期/Last Update: 2018-04-25