[1]倪杰明,倪安平.疟疾的固有免疫调节机制相关研究进展[J].中国药理学通报,2018,(05):612-615.[doi:10.3969/j.issn.1001-1978.2018.05.006]
 NI Jie-ming,NI An-ping.Research progress of regulation mechanism of innate immunity in malaria[J].Chinese Pharmacological Bulletin,2018,(05):612-615.[doi:10.3969/j.issn.1001-1978.2018.05.006]
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疟疾的固有免疫调节机制相关研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年05期
页码:
612-615
栏目:
讲座与综述
出版日期:
2018-05-26

文章信息/Info

Title:
Research progress of regulation mechanism of innate immunity in malaria
文章编号:
1001-1978(2018)05-0612-04
作者:
倪杰明1倪安平2
1.中国医科大学,辽宁 沈阳 110122;
2.中国医学科学院北京协和医学院检验科,北京 100730
Author(s):
NI Jie-ming1 NI An-ping2
1.China Medical University, Shenyang 110122,China;
2.Dept of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
关键词:
固有免疫 疟疾 巨噬细胞 单核细胞 树突状细胞 自然杀伤细胞 γδT细胞 自噬 靶向治疗
Keywords:
innate immunity malaria macrophage monocyte DC NK γδT cell autophagy targeted treatment
分类号:
R-05; R329.24; R392.12; R531.303
DOI:
10.3969/j.issn.1001-1978.2018.05.006
文献标志码:
A
摘要:
疟疾是一类对人类健康构成严重威胁的传染病,而疟原虫是其致病体。机体对包括疟原虫在内的外来抗原产生的免疫可分为固有免疫和适应性免疫,其中,固有免疫是一类非特异性的免疫反应,单核巨噬细胞、自然杀伤细胞(NK)、树突状细胞(DC)、γδT细胞、细胞因子等为固有免疫的重要组成部分,并与适应性免疫联动,有效抵抗机体疟原虫感染。同时,自噬不仅是细胞内自我降解的过程,也参与调节免疫系统功能,并对抗原虫感染。因此,相应免疫机制的阐述,可以为防治疟疾的相关药物、疫苗研发及临床治疗提供有效帮助。该文就疟疾中固有免疫的构成及其调节机制和相关治疗靶点研究进展进行综述。
Abstract:
Malaria is a kind of disease detrimental to human health and plasmodium is a critical pathogen in it. The immunity against foreign antigens including plasmodium could be divided into two categories, namely, adaptive immunity and innate immunity. Innate immunity induces non-specific immune response, and is composed of monocyte, macrophage, γδT cell, DC, NK, and cytokines etc. Innate immunity cooperates with adaptive immunity efficiently to protect against malaria. Meanwhile, autophagy is not only the cellular degrading process, but also gets involved in regulating immune system and defending against plasmodium infection. Therefore, elucidation of corresponding mechanism could provide proof for efficiently controlling and curing malaria, developing related medicine and vaccine, and clinical treatment as well. This article reviews the constitution of innate immunity in malaria, related regulation mechanism and relevant therapeutic targets for it.

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备注/Memo

备注/Memo:
收稿日期:2018-01-22,修回日期:2018-02-28
作者简介:倪杰明(1995-),男,七年制本科在读, E-mail:nijieming1995@163.com;
倪安平(1960-),男,硕士,教授,研究方向:病原微生物临床实验室诊断,通讯作者,E-mail:cotton1995@163.com
更新日期/Last Update: 2018-04-25