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Mitochondrial ATP-sensitive potassium channels and cardiovascular diseases
段 鹏12王金鑫1卫世强2段玉慧2朱庆磊1
1.解放军总医院心内科,北京 100853; 2.解放军371医院心内科,河南 新乡 453000
DUAN Peng12 WANG Jin-xin1 WEI Shi-qiang2 DUAN Yu-hui2 ZHU Qing-lei1
1.Cardiovascular Dept, Chinese PLA General Hospital, Beijing 100853, China; 2.Cardiovascular Dept, PLA No.371 Hospital, Xinxiang, Henan 453000, China
心血管疾病 线粒体ATP敏感钾通道 能量代谢 心功能不全 心律失常 糖尿病心肌病
cardiovascular diseases mitochondrial ATP-sensitive potassium channels energy metabolism cardiac failure arrhythmia diabetic cardiomyopathy
05; R329.24; R541.61; R541.7; R544; R542.2
With the aging of population and the changes of lifestyle, the cardiovascular diseases have become a serious threat to human health.Meanwhile, the cardiovascular death has become the chief death reason during recent epidemiological survey, so the prevention and treatment of cardiovascular diseases have become the focus of researches now.Mitochondrial ATP-sensitive potassium channels(mitoKATP)is an inward rectifier potassium channel located in the mitochondrial inner membrane, which has the effect of improving the energy metabolism, inhibiting the apoptosis, relieving the overload of Ca2+ and stabilizing the internal environment.Recently, some researchers have also found that mitoKATP can influence the development of cardiovascular diseases in different ways.This paper summarizes the structure and function of mitoKATP and the relationship between cardiovascular diseases and mitoKATP, aiming to clarify its role in the development of cardiovascular diseases.


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基金项目:国家自然科学基金资助项目(No 81570349)
作者简介:段 鹏(1985-),男,硕士生,研究方向:心血管药理学,E-mail:dp_2004_tmmu@163.com; 朱庆磊(1972-),男,博士,副研究员,硕士生导师,研究方向:心血管药理学,通讯作者,Tel:010-66936781,E-mail:qlzhu02@163.com
更新日期/Last Update: 2018-05-25