[1]段 鹏,王金鑫,卫世强,等.线粒体ATP敏感钾通道与心血管疾病[J].中国药理学通报,2018,(06):753-756.[doi:10.3969/j.issn.1001-1978.2018.06.004]
 DUAN Peng,WANG Jin-xin,WEI Shi-qiang,et al.Mitochondrial ATP-sensitive potassium channels and cardiovascular diseases[J].Chinese Pharmacological Bulletin,2018,(06):753-756.[doi:10.3969/j.issn.1001-1978.2018.06.004]
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线粒体ATP敏感钾通道与心血管疾病()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年06期
页码:
753-756
栏目:
讲座与综述
出版日期:
2018-06-26

文章信息/Info

Title:
Mitochondrial ATP-sensitive potassium channels and cardiovascular diseases
文章编号:
1001-1978(2018)06-0753-04
作者:
段 鹏12王金鑫1卫世强2段玉慧2朱庆磊1
1.解放军总医院心内科,北京 100853; 2.解放军371医院心内科,河南 新乡 453000
Author(s):
DUAN Peng12 WANG Jin-xin1 WEI Shi-qiang2 DUAN Yu-hui2 ZHU Qing-lei1
1.Cardiovascular Dept, Chinese PLA General Hospital, Beijing 100853, China; 2.Cardiovascular Dept, PLA No.371 Hospital, Xinxiang, Henan 453000, China
关键词:
心血管疾病 线粒体ATP敏感钾通道 能量代谢 心功能不全 心律失常 糖尿病心肌病
Keywords:
cardiovascular diseases mitochondrial ATP-sensitive potassium channels energy metabolism cardiac failure arrhythmia diabetic cardiomyopathy
分类号:
05; R329.24; R541.61; R541.7; R544; R542.2
DOI:
10.3969/j.issn.1001-1978.2018.06.004
文献标志码:
A
摘要:
随着人口老龄化的加剧以及生活方式的改变,心血管疾病成为严重威胁人类健康的重要疾病之一,而心血管死亡在近几年的流行病调查中也一直高居全因死亡的榜首,因此,心血管疾病的预防和治疗便成为现阶段各国科研和临床研究的重点。线粒体ATP敏感钾通道是位于线粒体内膜上的内向整流钾通道,具有改善能量代谢、抑制凋亡、减轻Ca2+超载、稳定内环境等作用。近期的研究发现,线粒体ATP敏感钾通道可通过不同的途径影响心血管疾病的发展。该文对线粒体ATP敏感钾通道的结构、功能及其与多种心血管疾病的关系进行了综述,明确其在心血管疾病发展中的作用。
Abstract:
With the aging of population and the changes of lifestyle, the cardiovascular diseases have become a serious threat to human health.Meanwhile, the cardiovascular death has become the chief death reason during recent epidemiological survey, so the prevention and treatment of cardiovascular diseases have become the focus of researches now.Mitochondrial ATP-sensitive potassium channels(mitoKATP)is an inward rectifier potassium channel located in the mitochondrial inner membrane, which has the effect of improving the energy metabolism, inhibiting the apoptosis, relieving the overload of Ca2+ and stabilizing the internal environment.Recently, some researchers have also found that mitoKATP can influence the development of cardiovascular diseases in different ways.This paper summarizes the structure and function of mitoKATP and the relationship between cardiovascular diseases and mitoKATP, aiming to clarify its role in the development of cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期:2018-02-02,修回日期:2018-03-15
基金项目:国家自然科学基金资助项目(No 81570349)
作者简介:段 鹏(1985-),男,硕士生,研究方向:心血管药理学,E-mail:dp_2004_tmmu@163.com; 朱庆磊(1972-),男,博士,副研究员,硕士生导师,研究方向:心血管药理学,通讯作者,Tel:010-66936781,E-mail:qlzhu02@163.com
更新日期/Last Update: 2018-05-25