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Polarization of microglia/macrophages and its role in ischemic stroke repair
朱 婷1孙桂波1孟祥宝1董东霞1赵立宇12孙晓波1
1.中国医学科学院北京协和医学院药用植物研究所,中药(天然产物)创新药物研发北京市重点实验室,北京 100193; 2.哈尔滨商业大学,黑龙江 哈尔滨 150000
ZHU Ting1 SUN Gui-bo1 Meng Xiang-bao1 Dong Dong-xia1 ZHAO Li-yu12 SUN Xiao-bo1
1.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences Peking Union Medical College; Beijing Key Lab of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine) and Translational Medicine, Beijing 100193, China; 2.Harbin University of Commerce, Harbin 150000, China
小胶质细胞/巨噬细胞 脑卒中 极化 M1/M2表型 炎症 治疗
microglia/macrophages ischemic stroke polarization M1/M2 phenotype inflammation treatment
R322.81; R329.24; R364.5; R392.12; R743.305
Traditionally, microglia/macrophage activation is thought to be detrimental in ischemic stroke.However, there is increasing evidence that microglia/macrophage activation is essential for attenuating neuronal apoptosis after cerebral ischemia, promoting neurogenesis and promoting functional recovery.Current research suggests that the inflammatory microenvironment greatly affects the phenotypic changes of microglia/macrophages, so that the same brain tissue has different gene expression patterns and biological functions at different stages of brain damage.This review provides a comprehensive review of the mechanisms of microglia/macrophage activation and the possible potential therapies.


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基金项目:国家自然科学基金资助项目(No 8177142084); 中国医学科学院医学与健康科技创新工程资助项目(No 2016-I2M-1-012)
作者简介:朱婷(1991-),女,博士生,研究方向: 脑血管药理学,E-mail: linlang0402@foxmail.com;
孙晓波(1958-),男,博士,教授,博士生导师,研究方向:中药及复方药效物质基础及分子机制,通讯作者,E-mail: sun-xiaobo@163.com;
孙桂波(1973-),女,博士,教授,博士生导师,研究方向:中药及复方药效物质基础及分子机制,通讯作者,E-mail: sunguibo@126.com
更新日期/Last Update: 2019-08-14