[1]李雪莲,李智洋,李宾公,等.NLRP3炎症小体与糖尿病性心肌病研究进展[J].中国药理学通报,2019,(08):1051-1054.[doi:10.3969/j.issn.1001-1978.2019.08.004]
 LI Xue-lian,LI Zhi-yang,LI Bin-gong,et al.Research progress of NLRP3 inflammasome in diabetic cardiomyopathy[J].Chinese Pharmacological Bulletin,2019,(08):1051-1054.[doi:10.3969/j.issn.1001-1978.2019.08.004]
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NLRP3炎症小体与糖尿病性心肌病研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年08期
页码:
1051-1054
栏目:
讲座与综述
出版日期:
2019-08-14

文章信息/Info

Title:
Research progress of NLRP3 inflammasome in diabetic cardiomyopathy
文章编号:
1001-1978(2019)08-1051-04
作者:
李雪莲1李智洋2李宾公1赖性君1
1.南昌大学第一附属医院心内科,江西 南昌 330006; 2.南京医科大学,江苏 南京 211166
Author(s):
LI Xue-lian1 LI Zhi-yang2 LI Bin-gong1 LAI Xing-jun1
1.Dept of Cardiology, the First Affiliated Hospital of Nanchang University,Nanchang 330006,China; 2.Nanjing Medical University, Nanjing 211166, China
关键词:
NLRP3 糖尿病心肌病 自噬 氧化应激 NF-κB 活性氧
Keywords:
NLRP3 DCM autophagy oxidative stress NF-κB reactive oxygen species
分类号:
R329.24; R364.5; R587.2
DOI:
10.3969/j.issn.1001-1978.2019.08.004
文献标志码:
A
摘要:
糖尿病的重要心血管并发症之一是糖尿病心肌病(diabetic cardiomyopathy,DCM)。代谢紊乱、线粒体损伤、心肌细胞凋亡和自噬都被证实参与了DCM的发生、发展。近年来研究证实,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体可能与DCM的发生、发展密切相关,是DCM治疗的潜在靶点。该文总结了NLRP3炎性小体与DCM的研究进展,为未来治疗DCM提供新的方向。
Abstract:
Diabetic cardiomyopathy(DCM)is one of the important cardiovascular complications of diabetes mellitus.Metabolic disorders, mitochondrial damage, cardiomyocyte apoptosis and autophagy are involved in the development of DCM.Recent research demonstrates that NLRP3 inflammasome plays a vital role in the pathogenesis of DCM, and has emerged as a potential target for the treatment of DCM.In this article, research progress in NLRP3 inflammasome and DCM has been reviewed, aiming to provide novel therapeutic idea for the treatment of DCM.

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备注/Memo

备注/Memo:
收稿日期:2019-04-20,修回日期:2019-05-25
基金项目:国家自然科学基金资助项目(No 81860052,81460046)
作者简介:李雪莲(1993-),女,硕士生,研究方向:糖尿病心肌病的机制,E-mail: lxl02914121@163.com;
李宾公(1972-),男,博士,教授,博士生导师,研究方向:心肌纤维化机制,通讯作者,E-mail: libingong08@163.com
更新日期/Last Update: 2019-08-14