[1]周 慧,陈 攀,许 静,等.赖氨酸甲基转移酶SETD6在肿瘤发生发展中的研究进展[J].中国药理学通报,2019,(08):1054-1057.[doi:10.3969/j.issn.1001-1978.2019.08.005]
 ZHOU Hui,CHEN Pan,XU Jing,et al.Progress of lysine methyltransferase SETD6 in cancer development[J].Chinese Pharmacological Bulletin,2019,(08):1054-1057.[doi:10.3969/j.issn.1001-1978.2019.08.005]
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赖氨酸甲基转移酶SETD6在肿瘤发生发展中的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年08期
页码:
1054-1057
栏目:
讲座与综述
出版日期:
2019-08-14

文章信息/Info

Title:
Progress of lysine methyltransferase SETD6 in cancer development
文章编号:
1001-1978(2019)08-1054-04
作者:
周 慧1陈 攀1许 静2陈 孝1陈 杰1
1.中山大学附属第一医院药学部,广东 广州 510080; 2.南方医科大学附属皮肤病医院药剂科,广东 广州 510091
Author(s):
ZHOU Hui1 CHEN Pan1 XU Jing2 CHEN Xiao1 CHEN Jie1
1.Dept of Pharmacy, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080,China; 2.Dept of Pharmacy, Dermatology Hospital, Southern Medical University,Guangzhou 510091, China
关键词:
SETD6 SET 肿瘤 信号通路 PKA4 Wnt/β-catenin NF-κB
Keywords:
SETD6 SET cancer signal pathway PKA4 Wnt/β-catenin NF-κB
分类号:
R341; R341.7; R345.5; R734.2; R735.35; R737.14; R737.9; R977.3
DOI:
10.3969/j.issn.1001-1978.2019.08.005
文献标志码:
A
摘要:
甲基化酶SET家族是治疗肝癌、乳腺癌、非小细胞肺癌等肿瘤潜在的基因靶点,近年来,其重要家族成员赖氨酸甲基转移酶SETD6的功能及作用引起人们的关注。SETD6不仅能够提高肿瘤细胞的生存、增殖及迁移能力,还能维持胚胎干细胞的自我更新、维持干细胞特性。其机制与SETD6通过甲基化PAK4蛋白激活Wnt/β-catenin通路,以及影响和调控NF-κB通路相关联。该文综述了SETD6在肿瘤发生、发展中的功能及其相关的分子基础、信号通路等研究,探讨其作为治疗肿瘤新靶点的应用前景。
Abstract:
Lysine methyltransferase SET is a potential gene target for the treatment of cancer such as hepatocellular carcinoma, human breast cancer and non-small cell lung cancer.SET domain containing 6(SETD6), as an important member of SET family, has been implicated in promoting cancer cell survival, proliferation and migration in recent years.SETD6 also plays a role in self-renewal of embryonic stem cell to maintain its characteristics.Functions of SETD6 were reported to be related to activation of Wnt/β-catenin pathway and inhibition of NF-κB-mediated inflammatory response by methylations of p21-activated kinase 4(PAK4)and RelA(P65)respectively.In this review, we would like to give summaries of the roles of SETD6 in cancer development and the corresponding molecular mechanisms, and discuss its application potential as a therapeutic target in cancer.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2019-04-19,修回日期:2019-05-17
基金项目:国家自然科学基金资助项目(No 81503156,81601347); 广东省自然科学基金资助项目(No 2018A030313138,2015A030313021)
作者简介:周 慧(1994-),女,硕士生,研究方向:临床药学,E-mail:zhouh73@mail2.sysu.edu.cn;
陈 杰(1971-),男,博士,副主任药师,研究方向:临床药学,通讯作者,E-mail:chenjiezs@163.com
更新日期/Last Update: 2019-08-14