[1]孟淑辉,李国铭,冯 梅,等.葛酮通络胶囊治疗脑梗死的作用机制及不良反应[J].中国药理学通报,2019,(08):1058-1060.[doi:10.3969/j.issn.1001-1978.2019.08.006]
 MENG Shu-hui,LI Guo-ming,FENG Mei,et al.Clinical pharmacology and adverse reactions of Ge Tong Tong Luo Capsule in treating cerebral infarction[J].Chinese Pharmacological Bulletin,2019,(08):1058-1060.[doi:10.3969/j.issn.1001-1978.2019.08.006]
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葛酮通络胶囊治疗脑梗死的作用机制及不良反应()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年08期
页码:
1058-1060
栏目:
讲座与综述
出版日期:
2019-08-14

文章信息/Info

Title:
Clinical pharmacology and adverse reactions of Ge Tong Tong Luo Capsule in treating cerebral infarction
文章编号:
1001-1978(2019)08-1058-03
作者:
孟淑辉1李国铭2冯 梅2吴光亮2蔡业峰123
1.广州中医药大学第二临床医学院脑病一科; 2.广东省中医院(广州中医药大学第二附属医院脑病科); 3.广东省中医药科学院,广东 广州 510120
Author(s):
MENG Shu-hui1 LI Guo-ming2 FENG Mei2 WU Guang-liang2 CAI Ye-feng123
1.First Dept of Neurology, the Second Clinical College of Guangzhou University of Chinese Medicine; 2.Guangdong Provincial Hospital of Traditional Chinese Medicine(the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine; 3.Guangdong Provincial Academy of Chinese Medicine, Guangzhou 510120, China
关键词:
葛酮通络胶囊 葛根总黄酮 脑梗死 药理 疗效 不良反应
Keywords:
Ge Tong Tong Luo Capsule pueraria flavonoids cerebral infarction pharmacology curative effect adverse reactions
分类号:
R-05; R282.71; R743.33.053.1; R916.4; R944.5
DOI:
10.3969/j.issn.1001-1978.2019.08.006
文献标志码:
A
摘要:
葛酮通络胶囊有效成分为葛根总黄酮,主要包括葛根素、黄豆苷元、大豆黄酮苷、大豆黄酮苷-4V等成分。在治疗脑梗死方面,葛酮通络胶囊及主要药理成分显示出抑制动脉粥样硬化斑块进展、清除氧自由基、抗血小板凝聚、抑制神经细胞凋亡等作用。在不良反应事件方面大多数研究均未出现药物所致的明显的不良反应,极少数研究虽出现心慌、咽干等不良反应事件,但多未经治疗而自行缓解。该文通过对葛酮通络胶囊及其主要药理成分的药理作用、临床疗效及不良反应情况进行介绍,为临床安全合理用药提供参考依据。
Abstract:
The active ingredient of Ge Tong Tong Luo Capsule is the total flavonoids of Pueraria lobata, which mainly consists of puerarin, daidzein, daidzein-4V and other components.In the treatment of cerebral infarction, Ge Tong Tong Luo Capsule and its main pharmacological components have shown to inhibit the progression of atherosclerotic plaque, scavenge oxygen free radicals, anti-platelet aggregation, and inhibit neuronal apoptosis.In terms of adverse events, most of the studies were obvious adverse reactions caused by drugs.In rare studies, although there were adverse events such as palpitation and dry throat, they were relieved without treatment.This article introduces the pharmacological effects, clinical efficacy and adverse reactions of Ge Tong Tong Luo Capsule and its main pharmacological components, and provides a reference for clinical safe and rational drug use.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2019-04-18,修回日期:2019-05-20
基金项目:广州市科技计划项目(No 201604020003); 广东省中医院中医药科学技术研究专项基金(No YN2016ZD04); 广东省中医院中医药科学技术研究专项基金(No YN2016ML09)
作者简介:孟淑辉(1985-),女,博士生,研究方向:脑血管病临床与基础,E-mail: msh889@126.com;
蔡业峰(1968-),男,博士,教授,博士生导师,研究方向:脑血管病临床与基础,通讯作者,E-mail: caiyefeng@126.com
更新日期/Last Update: 2019-08-14