[1]金 凡,朱盼虎,李家明,等.吡啶查尔酮类化合物对小鼠肝纤维化的作用[J].中国药理学通报,2019,(08):1183-1184.[doi:10.3969/j.issn.1001-1978.2019.08.028]
 JIN Fan,ZHU Pan-hu,LI Jia-ming,et al.Effect of pyridine chalcone on liver fibrosis in mice[J].Chinese Pharmacological Bulletin,2019,(08):1183-1184.[doi:10.3969/j.issn.1001-1978.2019.08.028]
点击复制

吡啶查尔酮类化合物对小鼠肝纤维化的作用()
分享到:

《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年08期
页码:
1183-1184
栏目:
研究简报
出版日期:
2019-08-14

文章信息/Info

Title:
Effect of pyridine chalcone on liver fibrosis in mice
文章编号:
1001-1978(2019)08-1183-02
作者:
金 凡1朱盼虎1李家明12黄元政1刘万冬1
安徽中医药大学1.药学院、2.安徽省中医药科学院药物化学研究所,安徽 合肥 230038
Author(s):
JIN Fan1 ZHU Pan-hu1 LI Jia-ming12 HUANG Yuan-zheng1 LIU Wan-dong1
1.College of Pharmacy, Anhui University of Chinese Medicine; 2.Dept of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230038,China
关键词:
肝纤维化 脂联素 HSC-T6 激动剂 小鼠 CCl4
Keywords:
liver fibrosis adiponectin HSC-T6 agonist mice CCl4
分类号:
R-332; R329.24; R347; R575.202; R916.4
DOI:
10.3969/j.issn.1001-1978.2019.08.028
文献标志码:
A

参考文献/References:

[1] Yamauchi T, Kamon J, Ito Y, et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J].Nature, 2007, 423(6941):762-8.
[2] Alzahrani B, Iseli T, Ramezanimoghadam M, et al.The role of AdipoR1 and AdipoR2 in liver fibrosis.[J].Biochimica Et Biophysica Acta, 2018, 1864(3):700-8.
[3] Kumar P, Smith T, Rahman K, et al.Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice[J].PLoS One, 2014, 9(10):e110405.
[4] 左龙泉,王 欢,汪应红,等.糖尿病高糖高脂对四氯化碳诱导的大鼠肝纤维化的作用研究[J].中国药理学通报, 2018,34(4):479-84.
[4] Zuo L Q, Wang H, Wang Y H, et al.Effect of diabetes high glucose and high fat on CCl4-induced liver fibrosis in mice[J].Chin Pharmacol Bull, 2018,34(4):479-84.
[5] Liu Y, Qi L H, Zhang Y F,et al.Inhibitory effects of six flavonoid compounds on collagen synthesis in rat hepatic stellate cells[J].J Pharm Pract, 2006, 24(2):83-6.
[6] Okada-Iwabu M, Yamauchi T, Iwabu M, et al.A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity[J].Nature, 2013,503:493-9.

相似文献/References:

[1]黄艳,黄成,李俊.肝纤维化病程中Kupffer细胞分泌的细胞因子对肝星状细胞活化增殖、凋亡的调控[J].中国药理学通报,2010,(01):9.
 HUANG Yan,HUANG Cheng,LI Jun.Effect of cytokines secreted from Kupffer cell on HSC proliferation, apoptosis in hepatic fibrosis process[J].Chinese Pharmacological Bulletin,2010,(08):9.
[2]王博龙.乌索酸对人肝星状细胞凋亡及TGFβ1mRNA表达的影响[J].中国药理学通报,2010,(03):417.
 WANG Bo long.[J].Chinese Pharmacological Bulletin,2010,(08):417.
[3]吴繁荣,陈飞虎,胡伟,等.鬼针草总黄酮抗大鼠免疫性肝纤维化作用及部分机制研究[J].中国药理学通报,2008,(06):0.
 WU Fan rong,CHEN Fei hu,HU Wei,et al.Antifibrosis effect and mechanism of total flavones of Bidens bipinnata L on immunological liver fibrosis in rats[J].Chinese Pharmacological Bulletin,2008,(08):0.
[4]孙利兵,王尉平,顾振纶,等.信号转导通路与肝纤维化[J].中国药理学通报,2008,(07):0.
 SUN Li bing,WANG Wei ping,GU Zhen lun,et al.Wnt signalling pathway and hepatic fibrosis[J].Chinese Pharmacological Bulletin,2008,(08):0.
[5]张怡,平洁,汪晖.肝星状细胞凋亡信号途径及其药物治疗的研究进展[J].中国药理学通报,2009,(01):0.
 ZHANG Yi,PING Jie,WANG Hui.The research progress of hepatic stellate cells apoptosis signaling pathway and the relative drugs[J].Chinese Pharmacological Bulletin,2009,(08):0.
[6]陈小亮,李俊,邓子煜,等.苦参素对肝纤维化大鼠肝脏TGFβ1的调节作用[J].中国药理学通报,2009,(06):0.
 CHEN Xiao liang,LI Jun,DENG Zi yu,et al.Regulating effect of oxymatrine on TGFβ1 in CCl4induced hepatic fibrosis rats[J].Chinese Pharmacological Bulletin,2009,(08):0.
[7]曹力波,李兵,李佐军,等.水飞蓟素对肝纤维化小鼠的保护作用及机制探讨[J].中国药理学通报,2009,(06):0.
 CAO Li bo,LI Bing,LI Zuo jun,et al.The effect and mechanism of Silymarin on liver fibrosis in mice[J].Chinese Pharmacological Bulletin,2009,(08):0.
[8]袁丽萍,陈飞虎,鹿玲,等.鬼针草总黄酮对肝纤维化大鼠肝星状细胞TGFβ1信号传导通路的影响[J].中国药理学通报,2009,(12):0.
 YUAN Li ping,CHEN Fei hu,LU Ling,et al.Effect of TFB on TGFβ1 signaling pathway in HSC of liver fibrosis rats[J].Chinese Pharmacological Bulletin,2009,(08):0.
[9]韦燕飞,刘雪梅,唐爱存,等.白花丹醌对瘦素刺激人肝星状细胞转化生长因子β1表达的影响[J].中国药理学通报,2010,(06):710.
 WEI Yan fei,LIU Xue mei,TANG Ai cun,et al.Effects of plumbagozeylanica (plumbago) on expression of transforming growth factor beta 1 in human hepatic stellate cells activated by leptin[J].Chinese Pharmacological Bulletin,2010,(08):710.
[10]刘雪梅,韦燕飞,彭岳,等.白花丹醌对瘦素诱导人肝星状细胞增殖与αSMA表达的影响[J].中国药理学通报,2010,(09):1154.
 LIU Xue mei,WEI Yan fei,PENG Yue,et al.Effects of plumbagozeylanica(plumbago)on expression of αSMA in human hepatic stellate cells activated by leptin[J].Chinese Pharmacological Bulletin,2010,(08):1154.

备注/Memo

备注/Memo:
收稿日期:2019-04-15,修回日期:2019-05-24
基金项目:安徽省重大科技专项资助项目(No 15czz01077)
作者简介:金 凡(1993-),男,硕士生,研究方向:药物化学设计与合成,E-mail: 2280925161@qq.com;
李家明(1964-),男,博士,教授,博士生导师,研究方向:药物化学设计与合成,通讯作者,Tel: 0551-68129147, E-mail: lijiaming2017@sina.com
更新日期/Last Update: 2019-08-14