[1]董一筱,张 钊,陈乃宏,等.应激对认知功能的影响及相关机制研究[J].中国药理学通报,2019,(09):1188-1193.[doi:10.3969/j.issn.1001-1978.2019.09.002]
 DONG Yi-xiao,ZHANG Zhao,CHEN Nai-hong.Effects of stress on cognitive function and its related mechanisms[J].Chinese Pharmacological Bulletin,2019,(09):1188-1193.[doi:10.3969/j.issn.1001-1978.2019.09.002]
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应激对认知功能的影响及相关机制研究()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年09期
页码:
1188-1193
栏目:
讲座与综述
出版日期:
2019-09-09

文章信息/Info

Title:
Effects of stress on cognitive function and its related mechanisms
文章编号:
1001-1978(2019)09-1188-05
作者:
董一筱12张 钊2陈乃宏1 2
1.天津中医药大学中药学院,天津 030619; 2.中国医学科学院药物研究所神经科学中心,天然药物活性物质与功能国家重点实验室,北京 100050
Author(s):
DONG Yi-xiao12 ZHANG Zhao2 CHEN Nai-hong12
1.School of Chinese Materia Medica, Tianjin University of Chinese Medicine, Tianjin 030619, China; 2.State Key Lab of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050,China
关键词:
应激 认知 良性应激 劣性应激 神经递质 糖皮质激素
Keywords:
stress cognition eustress distress neurotransmitter glucocorticoid
分类号:
R322.81; R338.1; R338.64; R395; R977.11
DOI:
10.3969/j.issn.1001-1978.2019.09.002
文献标志码:
A
摘要:
应激是人和大多数动物面对外界生存压力时普遍存在的一种应对机制,能调节个体的生理、心理功能及行为表现。研究表明,不同程度的应激对个体造成的应激反应及对认知的影响均有差异。对于不同的个体,同种应激源造成的应激反应也存在差异。这涉及神经递质及相关激素水平的改变,以及这种改变导致的下游信号通路不同的激活方式,也与个体的基因差异等因素有关。该文从神经递质、激素等作用及其下游机制方面,对不同程度应激状态所致的认知改变差异进行综述,进而为应激的合理应用及应激相关疾病的预防和治疗提供思路。
Abstract:
Stress is a kind of coping mechanism of human and most animals in the face of external survival pressure, which can regulate an individual's physiological, psychological function and behavior.Some studies have shown that there are differences in stress response and cognition of different stress intensity on individuals.In addition, for different individuals, the stress response caused by the same stress source is also varied, which is related to the changes in neurotransmitter and hormone levels, as well as difference in the activation patterns of downstream signaling pathways induced by such changes, which are also related to individual genetic difference and other factors.In this paper, the cognitive changes from different stress states are summarized from the aspects of neurotransmitters, hormones and their downstream mechanisms, so as to provide ideas for the reasonable application of stress and the prevention and treatment of stress-related diseases.

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备注/Memo

备注/Memo:
收稿日期:2019-05-13修回日期:2019-06-14
基金项目:国家自然科学基金资助项目(No 81603316,81603315); 中国医学科学院医学与健康科技创新工程经费资助(No 2016-I2M-1-004); 湖南省中药饮片标准化及功能工程技术研究中心开放基金资助项目(No BG201701)
作者简介:董一筱(1993-),男,硕士生,研究方向:神经药理学,Tel: 010-63165182,E-mail:yx_dong5265@163.com;
陈乃宏(1961-),男,博士,研究员,博士生导师,研究方向:神经系统疾患创新药物开发及作用机制,Tel/Fax: 010-63165177,E-mail:chennh@imm.ac.cn
更新日期/Last Update: 2019-08-14