[1]黄家喜,鲍翠玉,李 晶.PI3K/Akt通路在糖尿病心肌病中的研究进展[J].中国药理学通报,2019,(09):1202-1205.[doi:10.3969/j.issn.1001-1978.2019.09.005]
 HUANG Jia-xi,BAO Cui-yu,LI Jing.Research progress of PI3K/Akt pathway in diabetic cardiomyopathy[J].Chinese Pharmacological Bulletin,2019,(09):1202-1205.[doi:10.3969/j.issn.1001-1978.2019.09.005]
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PI3K/Akt通路在糖尿病心肌病中的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年09期
页码:
1202-1205
栏目:
讲座与综述
出版日期:
2019-09-09

文章信息/Info

Title:
Research progress of PI3K/Akt pathway in diabetic cardiomyopathy
文章编号:
1001-1978(2019)09-1202-04
作者:
黄家喜12鲍翠玉2李 晶2
湖北科技学院1.药学院、2.糖尿病心脑血管病变湖北省重点实验室,湖北 咸宁 437100
Author(s):
HUANG Jia-xi12 BAO Cui-yu2 LI Jing2
1.College of Pharmacy, 2.Hubei Province Key Lab on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, Hubei 437100, China
关键词:
糖尿病心肌病 PI3K/Akt 血糖 脂质代谢 内皮细胞 炎症
Keywords:
diabetic cardiomyopathy PI3K/Akt blood glucose lipid metabolism endothelial cells inflammation
分类号:
R-05; R322.11; R329.25; R364.5; R542.2; R587.2
DOI:
10.3969/j.issn.1001-1978.2019.09.005
文献标志码:
A
摘要:
糖尿病心肌病(diabetic cardiomyopathy,DCM)是由糖尿病引发心肌结构和功能的改变一类原发性心肌病变,区别于冠状动脉粥样硬化、高血压以及病毒等因素引起的继发性心肌病。磷酯酰肌醇3激酶(phosphatidylinositol-3 kinase,PI3K)/Akt作为人体重要的信号传导通路,参与机体正常生长繁殖、调节新陈代谢等功能。PI3K/Akt信号通路的调控因子包括沉默信息调节因子1、同源性磷酸酶-张力蛋白、糖原合成酶激酶3β、雷帕霉素靶蛋白等。DCM发病过程中,PI3K/Akt信号通路的作用包括调节血糖水平、调节脂质代谢、保护内皮细胞、减轻炎症反应、改善心功能并抵抗纤维化、调节心肌细胞凋亡等。PI3K-Akt信号通路抑制剂的研发为PI3K-Akt通路靶向治疗提供了可能性。该文综述了PI3K/Akt通路在DCM中的研究进展。
Abstract:
Diabetic cardiomyopathy(DCM)is a type of primary cardiomyopathy caused by diabetes, changing in the structure and function of the myocardium, which is distinguished from secondary cardiomyopathy resulted from coronary atherosclerosis, hypertension, and viruses.Phosphatidylinositol 3-kinase(PI3K)/Akt is an important signal transduction pathway in human body involved in the growth and reproduction of body.Regulatory factors of the PI3K/Akt signaling pathway include silencing information regulator 1, homologous phosphatase-tensin, glycogen synthase kinase 3β and the rapamycin target protein.The role of PI3K/Akt signaling pathway in the pathogenesis of DCM includes regulating blood sugar level, regulating lipid metabolism, protecting endothelial cells, reducing inflammatory response, improving cardiac function, resisting fibrosis, and regulating myocardial apoptosis.The development of PI3K-Akt signaling pathway inhibitors provides the possibility for PI3K-Akt pathway targeted therapy.This article reviews the progression of the PI3K/Akt pathway in DCM.

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备注/Memo

备注/Memo:
收稿日期:2019-04-14,修回日期:2019-05-22
基金项目:国家自然科学基金资助项目(No 51703055); 湖北省自然科学基金资助项目(No 2017CFB699,2015CFC773); 湖北省教育厅科学研究计划项目(No B201696); 湖北科技学院糖尿病专项基金(No 2016-18XZ09,14ZX-02)
作者简介:黄家喜(1990-),男,硕士生,研究方向:心血管药理学,E-mail:huangjiaxi0455@yeah.net;
李 晶(1979-),女,博士,副教授,研究方向:糖尿病心脑血管病变,通讯作者,E-mail:lijing790629@163.com
更新日期/Last Update: 2019-08-14