[1]吴紫君,杨超燕,张锦红,等.基于层次分析法的红色毛癣菌感染豚鼠模型评价[J].中国药理学通报,2019,(09):1325-1330.[doi:10.3969/j.issn.1001-1978.2019.09.026]
 WU Zi-jun,YANG Chao-yan,ZHANG Jin-hong,et al.Evaluation of guinea pig skin infection model of Trichophyton rubrum based on analytic hierarchy process[J].Chinese Pharmacological Bulletin,2019,(09):1325-1330.[doi:10.3969/j.issn.1001-1978.2019.09.026]
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基于层次分析法的红色毛癣菌感染豚鼠模型评价()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年09期
页码:
1325-1330
栏目:
实验方法学
出版日期:
2019-09-09

文章信息/Info

Title:
Evaluation of guinea pig skin infection model of Trichophyton rubrum based on analytic hierarchy process
文章编号:
1001-1978(2019)09-1325-07
作者:
吴紫君1杨超燕1张锦红2古炽明3唐春萍1江 炜1邹国发1黄 娟1陈艳芬14
1.广东药科大学中药学院,2.广东药科大学实验动物中心, 3.广东省中医院外二科, 4.广州市新药筛选模型体系构建与应用重点实验室,广东 广州 510006
Author(s):
WU Zi-jun1 YANG Chao-yan1 ZHANG Jin-hong2 GU Chi-ming3TANG Chun-ping1 JIANG Wei1 ZOU Guo-fa1 HUANG Juan1 CHEN Yan-fen14
1.School of Traditional Chinese Medicine, 2.Laboratory Animal Centre, Guangdong Pharmaceutical University, 3.Surgical Dept, Guangdong Provincial Hospital of TCM, 4.Guangzhou Key Lab of Construction and Application of New Drug Screening Model Systems, Guangzhou 510006, China
关键词:
层次分析法 模型评价 红色毛癣菌 皮肤感染 免疫抑制 豚鼠
Keywords:
analytic hierarchy process model evaluation Trichophyton rubrum skin infection immunosuppression guinea pig
分类号:
R-332; R363-332; R379.9; R751.05; R978.5
DOI:
10.3969/j.issn.1001-1978.2019.09.026
文献标志码:
A
摘要:
目的 建立红色毛癣菌感染豚鼠模型的评价指标体系,综合评价不同的造模方法,优选红色毛癣菌皮肤感染动物模型。方法 通过文献调研和专家咨询确定模型评价指标,利用德尔菲法和层次分析法计算出各指标权重,建立红色毛癣菌感染豚鼠模型的综合评价指标体系,进一步以此体系综合评价多种红色毛癣菌皮肤感染动物模型,优选理想的动物模型。结果 实验结果确认该评价体系良好; 接受免疫抑制剂处理并重复接种红色毛癣菌的动物模型质量较佳,成功率更高。结论 本研究采用层次分析法建立的评价指标体系清晰、简便,优选的红色毛癣菌皮肤感染动物模型适合推广用于抗真菌药的药效学评价。
Abstract:
Aim To establish the evaluation system for guinea pig skin infection model of Trichophyton rubrum, and to evaluate different modeling methods and select the best skin infection ani-mal model of Trichophyton rubrum.Methods The evaluation index was determined by literature research and expert consultation, weight of each index was calculated by Delphi Method and the analytic hierarchy process(AHP), to establish a comprehensive evaluation system for guinea pig skin infection model of Trichophyton rubrum.Furthermore, various skin infection animal models of Trichophyton rubrum were evaluated by this system and the ideal animal model was selected.Results The evaluation system proved to be available.The animal model with immunosuppressive treatment and repeated inoculation with Trichophyton rubrum had better quality and higher success rate.Conclusions The evaluation system established by AHP is clear, simple and convenient; the optimized skin infection animal model of Trichophyton rubrum is suitable for the efficacy evaluation of anti-fungal infection drugs.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2019-04-24,修回日期:2019-06-11
基金项目:广东省公益研究与能力建设专项资金项目(No 2015A030302088); 广东药科大学创新强校工程资助项目(No 2016KZDXM039)
作者简介:吴紫君(1994-),女,硕士生,研究方向:中药药效评价与临床应用,E-mail:1062435377@qq.com;
陈艳芬(1977-),女,博士,教授,硕士生导师,研究方向:中药药效评价及毒理学、药理实验动物模型,通讯作者,E-mail:xwnai@163.com
更新日期/Last Update: 2019-08-14