[1]苏路路,管博文,樊飞跃,等.衰老细胞清除剂研究进展[J].中国药理学通报,2019,(10):1333-1337.[doi:10.3969/j.issn.1001-1978.2019.10.001]
 SU Lu-lu,GUAN Bo-wen,FAN Fei-yue,et al.Development of senolytics for selectively elimination of senescent cells[J].Chinese Pharmacological Bulletin,2019,(10):1333-1337.[doi:10.3969/j.issn.1001-1978.2019.10.001]
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衰老细胞清除剂研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年10期
页码:
1333-1337
栏目:
讲座与综述
出版日期:
2019-09-15

文章信息/Info

Title:
Development of senolytics for selectively elimination of senescent cells
文章编号:
1001-1978(2019)10-1333-05
作者:
苏路路1管博文1樊飞跃1李德冠2孟爱民1
1.中国医学科学院, 北京协和医学院医学实验动物研究所比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室, 新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心, 北京 100021; 2.中国医学科学院放射医学研究所,北京协和医学院,天津市放射医学与分子核医学重点实验室,天津 300192
Author(s):
SU Lu-lu1 GUAN Bo-wen1 FAN Fei-yue1 LI De-guan2 MENG Ai-min1
1.Comparative Medical Center,Institute of Lab Animal Sciences, CAMS&PUMC, NHC Key Lab of Human Disease Comparative Medicine; Beijing Key Lab for Animal Models of Emerging and Reemerging Infectious Diseases; Beijing Engineering Research Center for Lab Animal Models of Human Critical Diseases; Beijing 100021, China; 2.Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College; Tianjin Key Lab of Radiation Medicine and Molecular Nuclear Medicine, ...
关键词:
细胞衰老 老年性疾病 衰老细胞堆积 衰老相关分泌表型 衰老细胞清除剂 细胞凋亡
Keywords:
cellular senescence age-related diseases senescent cells accumulation senescence-associated secretory phenotype senolytics cell apoptosis
分类号:
R-05; R339.36; R339.38; R592
DOI:
10.3969/j.issn.1001-1978.2019.10.001
文献标志码:
A
摘要:
老龄化是许多慢性疾病的首要危险因素。细胞衰老与老龄化的关系一直是人们关注的热点。近年来研究显示,衰老细胞堆积是驱动老龄化和老年性疾病发生、发展的重要机制。衰老细胞成为防治老年病的一个新靶点,研发选择性清除衰老细胞的药物也成为热点。该文将对衰老细胞在老年病发生、发展过程中的作用,以及诱导衰老细胞凋亡的药物——衰老细胞清除剂的相关研究进行综述。
Abstract:
Aging is the primary risk factor for many of the most common chronic diseases.The association of cellular senescence with aging-associated conditions has gaining increasing attention.There is now considerable evidence that senescent cell accumulation is an underlying mechanism of aging and age-related diseases.Senescent cells have been emerging as a target for new therapeutic strategies against aging-related pathology.Herein, we review the evidence that cellular senescence drives age-related deterioration and senolytics produce beneficial effect by selective elimination of senescent cells.

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备注/Memo

备注/Memo:
收稿日期:2019-07-10,修回日期:2019-08-20基金项目:中国医学科学院医学与健康科技创新工程资助项目(No 2017-I2M-3-015); 国家重点研发计划资助项目(No 2017YFA0105204); 国家自然科学基金资助项目(No 81573094)作者简介:苏路路(1990-),女,博士生,研究方向:放化疗对造血免疫细胞损伤的发生机制,E-mail:sululu325@126.com; 孟爱民(1963-),女,硕士,研究员,研究方向:放化疗对造血免疫细胞损伤的发生机制,通讯作者,E-mail: ai_min_meng@126.com
更新日期/Last Update: 2019-09-15