[1]李文雄,丁 凡,王拥军,等.组织肾素-血管紧张素系统、维生素D受体和Wnt/β-catenin在慢性病中交互作用的研究进展[J].中国药理学通报,2019,(10):1338-1341.[doi:10.3969/j.issn.1001-1978.2019.10.002]
 LI Wen-xiong,DING Fan,WANG Yong-jun,et al.Research progress on interactions among tissue renin-angiotensin system, vitamin D receptor and Wnt/β-catenin in chronic diseases[J].Chinese Pharmacological Bulletin,2019,(10):1338-1341.[doi:10.3969/j.issn.1001-1978.2019.10.002]
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组织肾素-血管紧张素系统、维生素D受体和Wnt/β-catenin在慢性病中交互作用的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年10期
页码:
1338-1341
栏目:
讲座与综述
出版日期:
2019-09-15

文章信息/Info

Title:
Research progress on interactions among tissue renin-angiotensin system, vitamin D receptor and Wnt/β-catenin in chronic diseases
文章编号:
1001-1978(2019)10-1338-04
作者:
李文雄1丁 凡1王拥军12施 杞12张 岩12
1.上海中医药大学附属龙华医院脊柱病研究所,上海 200032; 2.教育部筋骨理论与治法重点实验室,上海 200032
Author(s):
LI Wen-xiong1 DING Fan1 WANG Yong-jun12 SHI Qi12 ZHANG Yan12
1.Dept of Orthopaedics, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2.Key Lab(Theory and Therapy of Muscles and Bones)of Ministry of Education, Shanghai 200032, China
关键词:
Wnt/β-catenin 肾素-血管紧张素系统 维生素D受体 慢性病 信号通路 机制研究
Keywords:
Wnt/β-catenin renin-angiotensin system vitamin D receptor chronic diseases signaling pathway mechanism study
分类号:
R331; R345; R392.11; R394.2; R54; R692; R977.3; R977.6
DOI:
10.3969/j.issn.1001-1978.2019.10.002
文献标志码:
A
摘要:
该文探讨Wnt/β-catenin信号通路、组织肾素-血管紧张素系统(RAS)和维生素D受体(VDR)通路在慢性非传染性疾病(简称“慢性病”)中的交互调控作用。RAS和Wnt/β-catenin信号通路相互作用可诱发多种慢性病的发生。VDR被激活后,通过多种途径阻断β-catenin与下游基因的作用,抑制Wnt信号通路,而且VDR的激动剂在全身循环和局部组织均能够抑制RAS的生物学作用。因此,Wnt/β-catenin信号通路、RAS和VDR在慢性病的病理生理过程中协同发挥着重要的生物调控作用。
Abstract:
This review discusses the mutual regulative effects of Wnt/β-catenin signaling pathway, tissue renin-angiotensin system(RAS)and vitamin D receptor(VDR)pathway in chronic non-infectious diseases(abbr.chronic diseases).The interaction between RAS and Wnt/β-catenin might induce the occurrence of multiple chronic diseases.The activation of VDR inhibits Wnt signaling transduction through blocking the action of β-catenin on down-stream genes via various pathways.Moreover, the agonists on VDR suppress the biological actions of RAS in whole circulation and local tissues.Thus, Wnt/β-catenin signaling pathway, RAS and VDR synergistically exert vital biological modulations on the pathophysiological process of chronic diseases.

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备注/Memo

备注/Memo:
收稿日期:2019-07-16,修回日期:2019-08-28 基金项目:国家自然科学基金资助(No 81774329, 81730107); 上海市自然科学基金(No 17ZR1430800); 上海市市级医疗卫生优秀学科带头人培养计划资助(No 2018BR03); 国家重点研发计划项目(No 2018YFC1704302); 科技部重大新药创制项目(No 2019ZX09201004-003-032) 作者简介:李文雄(1990-),男,博士生,研究方向:中药药理学,E-mail:liwenxiong666@qq.com; 张 岩(1978-),男,博士,研究员,博士生导师,研究方向:药理学,通讯作者,E-mail:medicineyan@aliyun.com
更新日期/Last Update: 2019-09-15