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Research progress of small molecule activators in Keap1-Nrf2-ARE signaling pathway
姚 娟 吴平安 李 芸 李越峰 刘东玲 刘雪枫
甘肃中医药大学药学院,甘肃 兰州 730000
YAO Juan WU Ping-an LI Yun LI Yue-feng LIU Dong-lin LIU Xue-feng
College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000,China
Keap1 Nrf2 ARE 信号通路 激活剂 研究进展
Keap1 Nrf2 ARE signaling pathway activator research progress
R282.71; R329.25; R349.1; R916.4; R977.6
Keap1-Nrf2-ARE pathway represents one of the most important cellular defense mechanisms against oxidative stress.The expression of various detoxifying, antioxidant defense enzymes and proteins depend on the activation of the Nrf2 signaling.Keap1-Nrf2-ARE signaling pathway has become an attractive target for the prevention and treatment of oxidative stress-related diseases including neurodegenerative, cancer, cardiovascular, metabolic and inflammatory diseases.Activating Nrf2 signaling pathway can prevent and treat various oxidative stress-induced diseases.Therefore, discovering and studying the activators of Nrf2 has received extensive attention from researchers.In this paper, we have summarized the mechanism of the Keap1-Nrf2-ARE pathway and the research progress of some small molecule activators in this pathway.


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收稿日期:2019-07-10,修回日期:2019-08-17 基金项目:甘肃中医药大学引进人才科研启动基金项目(No 2016YJRC-04); 甘肃省高校中(藏)药化学与质量研究省级重点实验室开放基金项目(No zzy-2016-05) 作者简介:姚 娟(1987-),女,博士,副教授,研究方向:药理学,E-mail: yaojuan05@163.com
更新日期/Last Update: 2019-09-15