[1]姚 娟,吴平安,李 芸,等.Keap1-Nrf2-ARE信号通路及其激活剂的研究进展[J].中国药理学通报,2019,(10):1342-1346.[doi:10.3969/j.issn.1001-1978.2019.10.003]
 YAO Juan,WU Ping-an,LI Yun,et al.Research progress of small molecule activators in Keap1-Nrf2-ARE signaling pathway[J].Chinese Pharmacological Bulletin,2019,(10):1342-1346.[doi:10.3969/j.issn.1001-1978.2019.10.003]
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Keap1-Nrf2-ARE信号通路及其激活剂的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年10期
页码:
1342-1346
栏目:
讲座与综述
出版日期:
2019-09-15

文章信息/Info

Title:
Research progress of small molecule activators in Keap1-Nrf2-ARE signaling pathway
文章编号:
1001-1978(2019)10-1342-05
作者:
姚 娟 吴平安 李 芸 李越峰 刘东玲 刘雪枫
甘肃中医药大学药学院,甘肃 兰州 730000
Author(s):
YAO Juan WU Ping-an LI Yun LI Yue-feng LIU Dong-lin LIU Xue-feng
College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000,China
关键词:
Keap1 Nrf2 ARE 信号通路 激活剂 研究进展
Keywords:
Keap1 Nrf2 ARE signaling pathway activator research progress
分类号:
R282.71; R329.25; R349.1; R916.4; R977.6
DOI:
10.3969/j.issn.1001-1978.2019.10.003
文献标志码:
A
摘要:
Keap1-Nrf2-ARE信号通路是细胞防御氧化应激损伤的最重要机制之一。许多具有解毒、抗氧化防御功能的蛋白质,其转录调控都依赖于Nrf2信号通路的激活。研究表明,Nrf2信号通路已成为氧化应激相关疾病(神经退行性疾病、癌症、心血管系统疾病、代谢和炎症等疾病)预防和治疗的靶点。因此,Nrf2信号通路的激活剂在多种氧化应激诱发的疾病方面都表现出良好的预防及治疗作用,发现及研究Nrf2信号通路的激活剂已越来越受到研究者们的重视。该文概述了Keap1-Nrf2-ARE通路的作用机制,并阐述了Keap1-Nrf2-ARE信号通路小分子激活剂的研究进展。
Abstract:
Keap1-Nrf2-ARE pathway represents one of the most important cellular defense mechanisms against oxidative stress.The expression of various detoxifying, antioxidant defense enzymes and proteins depend on the activation of the Nrf2 signaling.Keap1-Nrf2-ARE signaling pathway has become an attractive target for the prevention and treatment of oxidative stress-related diseases including neurodegenerative, cancer, cardiovascular, metabolic and inflammatory diseases.Activating Nrf2 signaling pathway can prevent and treat various oxidative stress-induced diseases.Therefore, discovering and studying the activators of Nrf2 has received extensive attention from researchers.In this paper, we have summarized the mechanism of the Keap1-Nrf2-ARE pathway and the research progress of some small molecule activators in this pathway.

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备注/Memo

备注/Memo:
收稿日期:2019-07-10,修回日期:2019-08-17 基金项目:甘肃中医药大学引进人才科研启动基金项目(No 2016YJRC-04); 甘肃省高校中(藏)药化学与质量研究省级重点实验室开放基金项目(No zzy-2016-05) 作者简介:姚 娟(1987-),女,博士,副教授,研究方向:药理学,E-mail: yaojuan05@163.com
更新日期/Last Update: 2019-09-15