[1]梁红霞,陈超然,伊 丹,等.N-(5-对氟苄叉基绕丹宁)环丙沙星酰胺衍生物对人肝癌细胞增殖、凋亡和自噬的影响[J].中国药理学通报,2019,(10):1479-1480.[doi:10.3969/j.issn.1001-1978.2019.10.027]
 LIANG Hong-xia,CHEN Chao-ran,YI Dan,et al.Effects of N-(5-fluorobenzylidene rhodanine)ciprofloxacin amide derivative on proliferation,apoptosis and autophagy of human hepatocarcinoma cells[J].Chinese Pharmacological Bulletin,2019,(10):1479-1480.[doi:10.3969/j.issn.1001-1978.2019.10.027]
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N-(5-对氟苄叉基绕丹宁)环丙沙星酰胺衍生物对人肝癌细胞增殖、凋亡和自噬的影响()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2019年10期
页码:
1479-1480
栏目:
研究简报
出版日期:
2019-09-15

文章信息/Info

Title:
Effects of N-(5-fluorobenzylidene rhodanine)ciprofloxacin amide derivative on proliferation,apoptosis and autophagy of human hepatocarcinoma cells
文章编号:
1001-1978(2019)10-1479-02
作者:
梁红霞1陈超然1伊 丹1余令兵2康玉华2胡国强3刘 彬1
河南大学1.护理与健康研究所、2.淮河临床学院、3.药学院,河南 开封 475004
Author(s):
LIANG Hong-xia1CHEN Chao-ran1YI Dan1YU Ling-bing2KANG Yu-hua2HU Guo-qiang3LIU Bin1
1.Institute of Nursing and Health,2.Huaihe Clinical College,3.College of Pharmacy,Henan University,Kaifeng Henan 475004,China
关键词:
环丙沙星绕丹宁酰胺 肝癌细胞 细胞增殖 凋亡 自噬 基因沉默
Keywords:
ciprofloxacin rhodanine amide derivative hepatocarcinoma cells cell proliferation apoptosis autophagy gene silence
分类号:
R329.24; R329.25; R735.7; R978; R979.1
DOI:
10.3969/j.issn.1001-1978.2019.10.027
文献标志码:
A

参考文献/References:

[1] Fedorowicz J,Saczewski J.Modifications of quinolones and fluoroquinolones:hybrid compounds and dual-action molecules[J].Monatsh Chem,2018,149(7):1199-245.
[2] Bisacchi G S,Hale M R.A “double-edged” scaffold:antitumor power within the antibacterial quinolone[J].Curr Med Chem,2016,23(6):520-77.
[3] 梁红霞,余艺华,王 萌,等.N甲基环丙沙星氟喹诺酮查尔酮类衍生物对人胰腺癌BxPC-3细胞凋亡和自噬的影响[J].中国药理学通报,2018,34(8):1013-8.
[3] Liang H X,Yu Y H,Wang M,et al.Effect of N-methylciprofloxacin-based fluoroquinolone-chalcone derivative on the apoptosis and autophagy of human pancreatic carcinoma BxPC-3 cells[J].Chin Pharmacol Bull,2018,34(8):1013-8.
[4] Gewirtz D A.The four faces of autophagy:implications for cancer therapy[J].Cancer Res,2014,74(3):647-51.
[5] Sun J P,Shi Z Y,Liu S M,et al.Trimethoxy-benzaldehyde levofloxacin hydrazone inducing the growth arrest and apoptosis of human hepatocarcinoma cells [J].Cancer Cell Int,2013,13(1):67.
[6] Liu L,Zhao W M,Yang X H,et al.Effect of inhibiting Beclin-1 expression on autophagy,proliferation and apoptosis in colorectal cancer[J].Oncol Lett,2017,14(4):4319-24.
[7] Pasquier B.Autophagy inhibitors[J].Cell Mol Life Sci,2016,73(5):985-1001.

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备注/Memo

备注/Memo:
收稿日期:2019-06-23,修回日期:2019-08-14 基金项目:国家自然科学基金资助项目(No 20872028,21072045); 河南省科技厅科技攻关重点项目(No 112102310307); 河南省教育厅科学技术研究重点项目(No 15A310016); 开封市科技发展计划项目(No 1503108) 作者简介:梁红霞(1967-),女,高级实验师,硕士生导师,研究方向:肿瘤分子药理学,E-mail:lianghongxia@henu.edu.cn; 陈超然(1975-),男,博士,副教授,硕士生导师,研究方向:分子药理学,通讯作者,Tel:0371-23880399,E-mail:kfccr@126.com; 刘 彬(1959-),男,硕士,教授,硕士生导师,研究方向:肿瘤分子生物学,通讯作者,E-mail:lbgood5912@sina.com
更新日期/Last Update: 2019-09-15